Genome Analysis Toolkit

Variant Discovery in High-Throughput Sequencing Data

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Developed in the Data Sciences Platform at the Broad Institute, the toolkit offers a wide variety of tools with a primary focus on variant discovery and genotyping. Its powerful processing engine and high-performance computing features make it capable of taking on projects of any size. Learn more

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    Yiming Shen

    Dear Team,


    I've noticed that ```--dont-trim-active-regions``` flag has been removed since Is there any substitution for this option? For the default False setting of this flag can sometimes lead to false negatives in extension sequences of active regions.




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