Thomas Bradley
Hello, I am Thomas, a bioinformatician researching ovarian cancer within the Brenton group at the Cancer Research UK Cambridge Institute, within the University of Cambridge, UK.
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Latest activity by Thomas Bradley-
Thomas Bradley created a post,
Confusion regarding the Picard EstimateLibraryComplexity utility
Hello,I am writing to inquire about the EstimateLibraryComplexity picard utility.The documentation for this tool describes how the method determines whether read pairs are duplicates or not and how...
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Thomas Bradley commented,
Hello, Apologies for the late reply. Thank you for the links, they were definitely informative for the question that I asked. I guess the normal samples can be useful to help detect detect technica...
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Thomas Bradley commented,
Hi Genevieve Brandt (she/her),Thank you very much for your response.Ah yes, I forgot about this - some of the variants in the primary tumour will also be likely classed as germline.I agree, I don't...
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Thomas Bradley created a post,
Mutect2 - using a primary tumour sample instead of a normal sample
Hello,I am interested in a matched analysis not necessarily between normal samples vs. tumour samples - but rather primary tumour samples vs relapse tumour samples.The following FAQ (point 6), sugg...
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Thomas Bradley created a post,
Applying Mutect2 to targeted gene sequencing panels
Hello,I would like to ask about a potential analysis using mutect2 which I am not too sure about pleaseIf you are investigating somatic mutations in a tumour sample using targeted gene sequencing m...