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Genome Analysis Toolkit

Variant Discovery in High-Throughput Sequencing Data

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Developed in the Data Sciences Platform at the Broad Institute, the toolkit offers a wide variety of tools with a primary focus on variant discovery and genotyping. Its powerful processing engine and high-performance computing features make it capable of taking on projects of any size. Learn more

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Documentation Questions

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Show all All Planned Not planned Completed Answered No status Sort by newest post Newest post Recent activity Votes Comments
  • How is AC calculated?
    • mk
    • April 12, 2020 22:30
    0 votes 1 comment
  • How are the QC annotations combined into a single site/allele specific annotation from each individual QC annotations, such as FS, SOR, ReadPosRankSum?
    • WC
    • April 10, 2020 19:40
    • Edited
    0 votes 1 comment
  • vcf files for BQSR step Answered
    • Varun Gupta
    • March 30, 2020 22:13
    1 vote 4 comments
  • germline-resource Answered
    • Juechen Yang
    • March 17, 2020 17:32
    0 votes 10 comments
  • Recent research papers on current GATK
    • WVNicholson
    • March 16, 2020 17:29
    0 votes 1 comment
  • GATK4.1.5 GenotypeGVCFs --annotation-group
    • hana lango allen
    • March 12, 2020 16:06
    2 votes 1 comment
  • Updating from GATK 3 to GATK4 Mutect2 commands
    • Nisa Akhter
    • March 10, 2020 08:09
    0 votes 1 comment
  • CalculateGenotypePosteriors - pedigree relationships used
    • GE
    • February 10, 2020 22:54
    0 votes 1 comment
  • Joint Variant Calling of samples coming from different batches (different genome build or target chip)
    • Samreen Zafer
    • January 28, 2020 23:04
    0 votes 1 comment
  • postive AS_MQRankSum and VQSR
    • timh
    • January 23, 2020 12:18
    0 votes 1 comment
  • Tooldoc Suggestions for GATK and Picard Answered
    • johnma
    • January 17, 2020 16:09
    0 votes 1 comment
  • GATK Best Practices Mitochondrial Analysis Answered
    • ajwils
    • January 09, 2020 21:15
    • Edited
    1 vote 45 comments
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