Dear professor,
Thanks a lot.
I met a variant called by vardict in EGFR EXON19.

chr7    55242462    .    CAAGGAATT    C    .    clustered_events    AS_FilterStatus=SITE;AS_SB_TABLE=584,592|68,88;DP=1375;ECNT=10;GERMQ=93;MBQ=20,20;MFRL=132,135;MMQ=60,60;MPOS=21;POPAF=7.30;ROQ=93;TLOD=466.36;ANNOVAR_DATE=2020-06-08;Func.refGeneWithVer=exonic;Gene.refGeneWithVer=EGFR;GeneDetail.refGeneWithVer=.;ExonicFunc.refGeneWithVer=frameshift_deletion;AAChange.refGeneWithVer=EGFR:NM_005228.4:exon19:c.2233_2240del:p.E746Rfs*14;1000g2015aug_all=.;AF=.;AF_popmax=.;AF_male=.;AF_female=.;AF_raw=.;AF_afr=.;AF_sas=.;AF_amr=.;AF_eas=.;AF_nfe=.;AF_fin=.;AF_asj=.;AF_oth=.;non_topmed_AF_popmax=.;non_neuro_AF_popmax=.;non_cancer_AF_popmax=.;controls_AF_popmax=.;CLNALLELEID=.;CLNDN=.;CLNDISDB=.;CLNREVSTAT=.;CLNSIG=.;CLNHGVS=.;avsnp150=.;cosmic94=.;Alt=.;#Chr=.;Start=.;DamagePredCount=.;SIFT_pred=.;SIFT4G_pred=.;LRT_pred=.;MutationTaster_pred=.;MutationAssessor_pred=.;FATHMM_pred=.;PROVEAN_pred=.;MetaSVM_pred=.;MetaLR_pred=.;M-CAP_pred=.;MutPred_score=.;MVP_score=.;MPC_score=.;PrimateAI_pred=.;DEOGEN2_pred=.;BayesDel_addAF_pred=.;BayesDel_noAF_pred=.;LIST-S2_pred=.;DANN_score=.;fathmm-MKL_coding_pred=.;fathmm-XF_coding_pred=.;Eigen-raw_coding=.;Eigen-phred_coding=.;Eigen-PC-raw_coding=.;Eigen-PC-phred_coding=.;integrated_fitCons_score=.;GM12878_fitCons_score=.;H1-hESC_fitCons_score=.;HUVEC_fitCons_score=.;GERP++_NR=.;GERP++_RS=.;phyloP100way_vertebrate=.;phyloP30way_mammalian=.;phyloP17way_primate=.;phastCons100way_vertebrate=.;phastCons30way_mammalian=.;phastCons17way_primate=.;bStatistic=.;Interpro_domain=.;GTEx_V8_gene=.;GTEx_V8_tissue=.;ALLELE_END    GT:AD:AF:DP:F1R2:F2R1:FAD:SB    0/1:1176,156:0.124:1332:298,45:325,38:734,103:584,592,68,88

chr7    55242490    .    A    AAAGCCAAC    .    clustered_events;slippage    AS_FilterStatus=SITE;AS_SB_TABLE=446,445|43,42;DP=1104;ECNT=10;GERMQ=93;MBQ=20,20;MFRL=144,147;MMQ=60,60;MPOS=35;POPAF=7.30;ROQ=93;RPA=1,2;RU=AAGCCAAC;STR;STRQ=1;TLOD=289.35;ANNOVAR_DATE=2020-06-08;Func.refGeneWithVer=exonic;Gene.refGeneWithVer=EGFR;GeneDetail.refGeneWithVer=.;ExonicFunc.refGeneWithVer=frameshift_insertion;AAChange.refGeneWithVer=EGFR:NM_005228.4:exon19:c.2260_2261insAAGCCAAC:p.E758Pfs*11;1000g2015aug_all=.;AF=.;AF_popmax=.;AF_male=.;AF_female=.;AF_raw=.;AF_afr=.;AF_sas=.;AF_amr=.;AF_eas=.;AF_nfe=.;AF_fin=.;AF_asj=.;AF_oth=.;non_topmed_AF_popmax=.;non_neuro_AF_popmax=.;non_cancer_AF_popmax=.;controls_AF_popmax=.;CLNALLELEID=.;CLNDN=.;CLNDISDB=.;CLNREVSTAT=.;CLNSIG=.;CLNHGVS=.;avsnp150=.;cosmic94=.;Alt=.;#Chr=.;Start=.;DamagePredCount=.;SIFT_pred=.;SIFT4G_pred=.;LRT_pred=.;MutationTaster_pred=.;MutationAssessor_pred=.;FATHMM_pred=.;PROVEAN_pred=.;MetaSVM_pred=.;MetaLR_pred=.;M-CAP_pred=.;MutPred_score=.;MVP_score=.;MPC_score=.;PrimateAI_pred=.;DEOGEN2_pred=.;BayesDel_addAF_pred=.;BayesDel_noAF_pred=.;LIST-S2_pred=.;DANN_score=.;fathmm-MKL_coding_pred=.;fathmm-XF_coding_pred=.;Eigen-raw_coding=.;Eigen-phred_coding=.;Eigen-PC-raw_coding=.;Eigen-PC-phred_coding=.;integrated_fitCons_score=.;GM12878_fitCons_score=.;H1-hESC_fitCons_score=.;HUVEC_fitCons_score=.;GERP++_NR=.;GERP++_RS=.;phyloP100way_vertebrate=.;phyloP30way_mammalian=.;phyloP17way_primate=.;phastCons100way_vertebrate=.;phastCons30way_mammalian=.;phastCons17way_primate=.;bStatistic=.;Interpro_domain=.;GTEx_V8_gene=.;GTEx_V8_tissue=.;ALLELE_END    GT:AD:AF:DP:F1R2:F2R1:FAD:SB    0/1:891,85:0.094:976:241,29:260,23:567,58:446,445,43,42

is this a real variant?