"Has there been any validation done on WES data?"
"We have not been running functional equivalence evaluation for exomes. We have only looked at whole genomes at this point. We expect the results to be very similar. At this point we cannot guarantee that you will be able to combine exome data with DRAGEN and DRAGEN-GATK without batch effects. Although it is use at your own risk, it could be very well that they are functionally equivalent. At this point we cannot guarantee that."
"It should be very straight forward running DRAGEN-GATK on exome. I know that WARP (a collection of open source WDL pipelines to run all sorts of genomic analyses) has a pipeline for running whole exome data. If running with this WARP exome pipeline, I don't predict any complications. If they are functionally equivalent, we don't know."
-Michael Gatzen, Broad
The recording of the DRAGEN-GATK webinar and this Q&A session will be released within the next month. For more information on DRAGEN-GATK, please see this page: https://gatk.broadinstitute.org/hc/en-us/articles/360045944831
Edit: The DRAGEN-GATK Webinar Recording has been uploaded!
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