Genome Analysis Toolkit

Variant Discovery in High-Throughput Sequencing Data

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Developed in the Data Sciences Platform at the Broad Institute, the toolkit offers a wide variety of tools with a primary focus on variant discovery and genotyping. Its powerful processing engine and high-performance computing features make it capable of taking on projects of any size. Learn more

MGI DNBSEQ-T7 DNA Sequencer (Nebula) ….Is it Compatible with GATK Best Practice Pipeline?



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    Completely compatible. Use ILLUMINA as platform tag in sam file. Picard or GATK does not accept MGI as platform name. General base quality and call metrics are very compatible with earlier ILLUMINA devices such as HiSeq 2000 2500. T7 might have adopted something similar to Novaseq but I am not sure. I can talk for DNB-SEQ G400 AKA MGISEQ-2000 and the experience has been quite familiar. 

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    Genevieve Brandt (she/her)

    Hi Adi Abuali,

    Could you provide more information about the similarities and differences between the sequencing you have and Illumina sequencing? I am not familiar enough with the data you have to make good recommendations at this point.

    Please see this document for what you should include in your post:

    Thank you!


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    Adi Abuali

    Thank you SkyWarrior...

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