Are there details available about how exactly af-only-gnomad.hg38.vcf.gz was created?
I've seen elsewhere that it was generated from one of the Gnomad v2 versions (not sure which exactly) and is a merge of the exome and genome data lifted over to hg38, but could not find specifics and could not easily reverse engineer the values.
Specifically, what Gnomad field(s) were used to to compute the AF value in af-only-gnomad.hg38.vcf.gz ? Is it just computed from a merged tally of AC and AN from the exome and genome files?
Also, has any consideration been given to using AF_popmax and/or including Gnomad v3? Either of these could potentially make a big difference for previously underrepresented populations.
Thanks very much.
Please sign in to leave a comment.