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Variant Discovery in High-Throughput Sequencing Data

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Developed in the Data Sciences Platform at the Broad Institute, the toolkit offers a wide variety of tools with a primary focus on variant discovery and genotyping. Its powerful processing engine and high-performance computing features make it capable of taking on projects of any size. Learn more

Funcotator Errors : I/O error in the advisory file locking logic (disk I/O error)


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    Genevieve Brandt (she/her)

    Hi Min-Hwan Sohn,

    This does not look like an issue with your files or reference file versions. We have seen this issue before and there is more information at that link about what might be going on. It is most likely an issue with your file system and SQL Lite not working well with that system. 

    What is your file system where you are running and storing Funcotator?

    You may be able to disable the cosmic data source which will remove the SQL Lite requirements. You can also try to run it on your local or non-distributed file system.

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