What is the training data for the model - based filters?

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Yuting He

• November 17, 2020 15:53

a)How do I (......)?

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  Kate Herman

  • November 18, 2020 16:12
  • Edited

  This question was answered during our live webinar. The answer is copied below for posterity.

   

  A: Each of the model based filters uses the data you provide to M2 and FilterMutectCalls. As an example, the read orientation filters use statistics collected from LearnReadOrientationModel. These statistics are plugged into a model that is then used to filter variants.

  We don’t use a training set that explicitly labels true and false variants.

  - Mark Fleharty

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