Error in running SplitNCigarReads - htsjdk.samtools.util.RuntimeIOException
AnsweredI am trying to run SplitNCigarReads on RNA-Seq BAM files generated from STAR and put through picard MarkDuplicates. I used picard AddOrReplaceReadGroups to add read group information to the deduped BAM. I check the BAM file with picard ValidateSamFile again and the only warning I have is WARNING:MISSING_TAG_NM. I am using GATK v4.1.6.0-2-gcbbbb7a-SNAPSHOT and the command and error log are shown below. I thought increasing the amount of RAM and reads in memory would help, but it didn't seem to make much of a difference. I still see the same error.
Command:
/opt/gatk/gatk --java-options "-Xms60g -Xmx100G" SplitNCigarReads -R /home/kjngo/software/Reference_Genomes/STAR_indices_overhang75_hg38/GrCh38-genome.fa -I 1-2_S28_marked_duplicates_RG.bam -O 1-2_S28_marked_duplicates_splitNCigarReads.bam --max-reads-in-memory 2000000
Log:
Using GATK jar /opt/gatk/build/libs/gatk-package-4.1.6.0-2-gcbbbb7a-SNAPSHOT-local.jar
Running:
java -Dsamjdk.use_async_io_read_samtools=false -Dsamjdk.use_async_io_write_samtools=true -Dsamjdk.use_async_io_write_tribble=false -Dsamjdk.compression_level=2 -Xms60g -Xmx100G -jar /opt/gatk/build/libs/gatk-package-4.1.6.0-2-gcbbbb7a-SNAPSHOT-local.jar SplitNCigarReads -R /home/kjngo/software/Reference_Genomes/STAR_indices_overhang75_hg38/GrCh38-genome.fa -I 1-2_S28_marked_duplicates_RG.bam -O 1-2_S28_marked_duplicates_splitNCigarReads.bam --max-reads-in-memory 2000000
22:37:38.541 INFO NativeLibraryLoader - Loading libgkl_compression.so from jar:file:/opt/gatk/build/libs/gatk-package-4.1.6.0-2-gcbbbb7a-SNAPSHOT-local.jar!/com/intel/gkl/native/libgkl_compression.so
Aug 26, 2020 10:37:38 PM shaded.cloud_nio.com.google.auth.oauth2.ComputeEngineCredentials runningOnComputeEngine
INFO: Failed to detect whether we are running on Google Compute Engine.
22:37:38.796 INFO SplitNCigarReads - ------------------------------------------------------------
22:37:38.796 INFO SplitNCigarReads - The Genome Analysis Toolkit (GATK) v4.1.6.0-2-gcbbbb7a-SNAPSHOT
22:37:38.796 INFO SplitNCigarReads - For support and documentation go to https://software.broadinstitute.org/gatk/
22:37:38.797 INFO SplitNCigarReads - Executing as kjngo@### on Linux v4.15.0-112-generic amd64
22:37:38.797 INFO SplitNCigarReads - Java runtime: OpenJDK 64-Bit Server VM v1.8.0_265-8u265-b01-0ubuntu2~18.04-b01
22:37:38.797 INFO SplitNCigarReads - Start Date/Time: August 26, 2020 10:37:38 PM PDT
22:37:38.797 INFO SplitNCigarReads - ------------------------------------------------------------
22:37:38.797 INFO SplitNCigarReads - ------------------------------------------------------------
22:37:38.798 INFO SplitNCigarReads - HTSJDK Version: 2.21.2
22:37:38.798 INFO SplitNCigarReads - Picard Version: 2.21.9
22:37:38.798 INFO SplitNCigarReads - HTSJDK Defaults.COMPRESSION_LEVEL : 2
22:37:38.798 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_READ_FOR_SAMTOOLS : false
22:37:38.798 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_SAMTOOLS : true
22:37:38.798 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_TRIBBLE : false
22:37:38.798 INFO SplitNCigarReads - Deflater: IntelDeflater
22:37:38.798 INFO SplitNCigarReads - Inflater: IntelInflater
22:37:38.798 INFO SplitNCigarReads - GCS max retries/reopens: 20
22:37:38.798 INFO SplitNCigarReads - Requester pays: disabled
22:37:38.798 INFO SplitNCigarReads - Initializing engine
22:37:39.093 INFO SplitNCigarReads - Done initializing engine
22:37:39.128 INFO ProgressMeter - Starting traversal
22:37:39.128 INFO ProgressMeter - Current Locus Elapsed Minutes Reads Processed Reads/Minute
22:37:49.219 INFO ProgressMeter - chr1:6269805 0.2 388000 2307234.9
22:37:59.227 INFO ProgressMeter - chr1:11786841 0.3 562000 1677695.4
22:38:09.268 INFO ProgressMeter - chr1:16575376 0.5 725000 1443264.8
22:38:19.274 INFO ProgressMeter - chr1:21219730 0.7 890000 1330145.0
22:38:29.302 INFO ProgressMeter - chr1:24531817 0.8 1037000 1240084.5
22:38:39.326 INFO ProgressMeter - chr1:26781521 1.0 1188000 1184092.5
22:38:49.367 INFO ProgressMeter - chr1:28606828 1.2 1330000 1136121.0
22:38:59.482 INFO ProgressMeter - chr1:32193214 1.3 1540000 1149911.6
22:39:09.484 INFO ProgressMeter - chr1:35533565 1.5 1662000 1103634.5
22:39:19.487 INFO ProgressMeter - chr1:36475902 1.7 1787000 1068375.2
22:39:29.543 INFO ProgressMeter - chr1:39237906 1.8 1847000 1003677.1
22:39:39.571 INFO ProgressMeter - chr1:40397681 2.0 1985000 988849.5
22:39:49.632 INFO ProgressMeter - chr1:43393529 2.2 2144000 985716.9
22:39:59.718 INFO ProgressMeter - chr1:46342772 2.3 2227000 950430.0
22:40:09.818 INFO ProgressMeter - chr1:52358374 2.5 2357000 938489.2
22:40:19.864 INFO ProgressMeter - chr1:55154496 2.7 2450000 914548.8
22:40:29.924 INFO ProgressMeter - chr1:64851837 2.8 2555000 897562.0
22:40:40.706 INFO ProgressMeter - chr1:67424237 3.0 2676000 884253.0
22:40:50.735 INFO ProgressMeter - chr1:84208508 3.2 2819000 882744.4
22:41:00.741 INFO ProgressMeter - chr1:89260093 3.4 2992000 890418.8
22:41:10.778 INFO ProgressMeter - chr1:97374235 3.5 3262000 924738.6
22:41:20.800 INFO ProgressMeter - chr1:107756145 3.7 3464000 937605.7
22:41:30.928 INFO ProgressMeter - chr1:110406321 3.9 3584000 927696.3
22:41:41.010 INFO ProgressMeter - chr1:112586295 4.0 3709000 920039.2
22:41:51.040 INFO ProgressMeter - chr1:116527710 4.2 3848000 916510.5
22:42:01.085 INFO ProgressMeter - chr1:120270031 4.4 4073000 932904.8
22:42:11.111 INFO ProgressMeter - chr1:120841657 4.5 4231000 933370.6
22:42:21.125 INFO ProgressMeter - chr1:145036554 4.7 4438000 944268.7
22:42:34.523 INFO ProgressMeter - chr1:145992882 4.9 4572000 928658.0
22:42:44.548 INFO ProgressMeter - chr1:146351250 5.1 4776000 938249.0
22:42:54.584 INFO ProgressMeter - chr1:148773179 5.3 4992000 949482.7
22:43:04.594 INFO ProgressMeter - chr1:149666097 5.4 5204000 959365.8
22:43:14.607 INFO ProgressMeter - chr1:150578251 5.6 5342000 955410.0
22:43:24.665 INFO ProgressMeter - chr1:151365772 5.8 5495000 954167.0
22:43:34.725 INFO ProgressMeter - chr1:151982967 5.9 5527000 932572.5
22:43:44.767 INFO ProgressMeter - chr1:154251107 6.1 5684000 932723.3
22:43:54.777 INFO ProgressMeter - chr1:155481709 6.3 5803000 926875.9
22:44:04.816 INFO ProgressMeter - chr1:156959126 6.4 5914000 920020.6
22:44:14.869 INFO ProgressMeter - chr1:158999931 6.6 6050000 917266.6
22:44:24.959 INFO ProgressMeter - chr1:160996477 6.8 6216000 919003.2
22:44:41.641 INFO ProgressMeter - chr1:161589598 7.0 6376000 905439.6
22:44:51.673 INFO ProgressMeter - chr1:167634190 7.2 6629000 919534.4
22:45:01.711 INFO ProgressMeter - chr1:171512179 7.4 6785000 919829.5
22:45:11.719 INFO ProgressMeter - chr1:174845180 7.5 6944000 920566.3
22:45:21.725 INFO ProgressMeter - chr1:178888980 7.7 7085000 918942.4
22:45:31.814 INFO ProgressMeter - chr1:182828968 7.9 7240000 919003.3
22:45:44.619 INFO ProgressMeter - chr1:183573231 8.1 7302000 902428.5
22:45:54.661 INFO ProgressMeter - chr1:186893117 8.3 7523000 910899.8
22:46:04.669 INFO ProgressMeter - chr1:198652411 8.4 7676000 911024.0
22:46:14.966 INFO ProgressMeter - chr1:198737057 8.6 7830000 910752.8
22:46:24.990 INFO ProgressMeter - chr1:203775504 8.8 8075000 921344.4
22:46:37.733 INFO ProgressMeter - chr1:206558550 9.0 8202000 913695.4
22:46:47.733 INFO ProgressMeter - chr1:207768332 9.1 8361000 914428.4
22:46:57.734 INFO ProgressMeter - chr1:219988629 9.3 8544000 917713.0
22:47:07.755 INFO ProgressMeter - chr1:225854528 9.5 8688000 916734.5
22:47:17.823 INFO ProgressMeter - chr1:228147634 9.6 8835000 916026.6
22:47:27.836 INFO ProgressMeter - chr1:231813675 9.8 8944000 911555.5
22:47:37.850 INFO ProgressMeter - chr1:235804815 10.0 9102000 912144.4
22:47:47.951 INFO ProgressMeter - chr1:236542145 10.1 9148000 901542.8
22:47:57.961 INFO ProgressMeter - chr1:246507087 10.3 9333000 904896.8
22:48:14.455 INFO ProgressMeter - chr2:218802 10.6 9429000 890470.6
22:48:24.472 INFO ProgressMeter - chr2:23747590 10.8 9783000 909562.8
22:48:34.476 INFO ProgressMeter - chr2:27384891 10.9 9980000 913714.4
22:48:44.503 INFO ProgressMeter - chr2:32470276 11.1 10156000 915815.8
22:48:54.535 INFO ProgressMeter - chr2:39084057 11.3 10307000 915627.0
22:49:04.604 INFO ProgressMeter - chr2:44209284 11.4 10514000 920294.8
22:49:14.655 INFO ProgressMeter - chr2:53706789 11.6 10688000 922005.9
22:49:24.832 INFO ProgressMeter - chr2:61109295 11.8 10832000 920952.7
22:49:34.867 INFO ProgressMeter - chr2:64134995 11.9 10955000 918351.5
22:49:44.941 INFO ProgressMeter - chr2:69479381 12.1 11196000 925527.6
22:49:56.744 INFO ProgressMeter - chr2:70152757 12.3 11306000 919665.5
22:50:06.774 INFO ProgressMeter - chr2:74102370 12.5 11465000 920089.1
22:50:16.797 INFO ProgressMeter - chr2:85578166 12.6 11640000 921774.5
22:50:26.875 INFO ProgressMeter - chr2:88736569 12.8 11805000 922570.7
22:50:36.904 INFO ProgressMeter - chr2:97142308 13.0 11915000 919159.2
22:50:46.923 INFO ProgressMeter - chr2:98601595 13.1 12049000 917675.3
22:51:01.279 INFO ProgressMeter - chr2:101305523 13.4 12229000 914716.7
22:51:11.307 INFO ProgressMeter - chr2:106867828 13.5 12400000 916054.2
22:51:21.350 INFO ProgressMeter - chr2:113174894 13.7 12560000 916540.8
22:51:31.491 INFO ProgressMeter - chr2:121757235 13.9 12749000 918998.1
22:51:41.500 INFO ProgressMeter - chr2:128266279 14.0 12891000 918194.0
22:51:51.517 INFO ProgressMeter - chr2:136115139 14.2 13022000 916624.8
22:52:04.149 INFO ProgressMeter - chr2:143289728 14.4 13167000 913295.7
22:52:14.150 INFO ProgressMeter - chr2:148275640 14.6 13509000 926308.1
22:52:24.184 INFO ProgressMeter - chr2:159773892 14.8 13736000 931195.3
22:52:34.193 INFO ProgressMeter - chr2:167968915 14.9 13900000 931775.9
22:52:44.235 INFO ProgressMeter - chr2:173948120 15.1 14039000 930652.4
22:52:54.239 INFO ProgressMeter - chr2:174967245 15.3 14171000 929134.2
22:53:04.238 INFO ProgressMeter - chr2:181367796 15.4 14304000 927716.7
22:53:14.268 INFO ProgressMeter - chr2:190901914 15.6 14475000 928737.9
22:53:24.269 INFO ProgressMeter - chr2:197059920 15.8 14678000 931797.5
22:53:34.339 INFO ProgressMeter - chr2:197496699 15.9 14851000 932841.0
22:53:44.403 INFO ProgressMeter - chr2:201278237 16.1 15014000 933247.0
22:53:55.276 INFO ProgressMeter - chr2:201478191 16.3 15056000 925434.4
22:54:05.287 INFO ProgressMeter - chr2:207926645 16.4 15200000 924801.1
22:54:15.376 INFO ProgressMeter - chr2:218126105 16.6 15340000 923866.3
22:54:25.471 INFO ProgressMeter - chr2:219240994 16.8 15490000 923542.0
22:54:35.476 INFO ProgressMeter - chr2:227351286 16.9 15635000 923010.6
22:54:45.509 INFO ProgressMeter - chr2:230534629 17.1 15796000 923399.8
22:54:55.515 INFO ProgressMeter - chr2:233191153 17.3 15921000 921721.3
22:55:06.628 INFO ProgressMeter - chr2:234493821 17.5 15958000 914062.1
22:55:16.687 INFO ProgressMeter - chr2:241081356 17.6 16110000 913992.4
22:55:29.258 INFO ProgressMeter - chr3:181037 17.8 16168000 906506.7
22:55:39.290 INFO ProgressMeter - chr3:14142777 18.0 16541000 918806.6
22:55:49.314 INFO ProgressMeter - chr3:15738525 18.2 16764000 922631.6
22:55:59.321 INFO ProgressMeter - chr3:15738553 18.3 17111000 933164.4
22:56:09.321 INFO ProgressMeter - chr3:15738576 18.5 17461000 943674.6
22:56:19.320 INFO ProgressMeter - chr3:15738607 18.7 17812000 954050.7
22:56:33.684 INFO ProgressMeter - chr3:15738617 18.9 18128000 958684.2
22:56:43.710 INFO ProgressMeter - chr3:15738619 19.1 18474000 968423.4
22:56:53.726 INFO ProgressMeter - chr3:15738621 19.2 18816000 977794.9
22:57:03.758 INFO ProgressMeter - chr3:17543530 19.4 19082000 983077.0
22:57:13.829 INFO ProgressMeter - chr3:20072303 19.6 19153000 978274.5
22:57:23.839 INFO ProgressMeter - chr3:30690476 19.7 19332000 979074.2
22:57:33.890 INFO ProgressMeter - chr3:36989075 19.9 19498000 979174.1
22:57:43.907 INFO ProgressMeter - chr3:41236610 20.1 19624000 977308.7
22:57:53.906 INFO ProgressMeter - chr3:45835704 20.2 19777000 976820.5
22:58:03.930 INFO ProgressMeter - chr3:48440284 20.4 19887000 974215.4
22:58:13.936 INFO ProgressMeter - chr3:49721174 20.6 19999000 971763.2
22:58:24.131 INFO ProgressMeter - chr3:50413439 20.8 20072000 967323.0
22:58:34.214 INFO ProgressMeter - chr3:52837023 20.9 20173000 964380.9
22:58:44.224 INFO ProgressMeter - chr3:58403904 21.1 20311000 963294.5
22:58:54.318 INFO ProgressMeter - chr3:70951616 21.3 20492000 964185.7
22:59:04.343 INFO ProgressMeter - chr3:71773329 21.4 20650000 964041.0
22:59:14.389 INFO ProgressMeter - chr3:101445795 21.6 20805000 963744.0
22:59:24.409 INFO ProgressMeter - chr3:111545226 21.8 20967000 963793.2
22:59:34.521 INFO ProgressMeter - chr3:113382190 21.9 21036000 959530.7
22:59:44.556 INFO ProgressMeter - chr3:119675162 22.1 21211000 960188.0
22:59:54.573 INFO ProgressMeter - chr3:122715636 22.3 21373000 960264.2
23:00:04.638 INFO ProgressMeter - chr3:128156742 22.4 21496000 958566.6
23:00:14.704 INFO ProgressMeter - chr3:131016806 22.6 21624000 957113.4
23:00:24.748 INFO ProgressMeter - chr3:134640920 22.8 21727000 954599.4
23:00:34.822 INFO ProgressMeter - chr3:139348476 22.9 21903000 955285.1
23:00:44.844 INFO ProgressMeter - chr3:141436914 23.1 21925000 949329.4
23:00:54.904 INFO ProgressMeter - chr3:149701906 23.3 22074000 948891.5
23:01:04.945 INFO ProgressMeter - chr3:152307616 23.4 22239000 949156.3
23:01:14.956 INFO ProgressMeter - chr3:154255057 23.6 22393000 948971.2
23:01:24.969 INFO ProgressMeter - chr3:167693487 23.8 22545000 948703.3
23:01:34.988 INFO ProgressMeter - chr3:172204238 23.9 22673000 947432.2
23:01:45.180 INFO ProgressMeter - chr3:183018017 24.1 22845000 947891.2
23:01:57.164 INFO ProgressMeter - chr3:183845464 24.3 22874000 941293.6
23:02:07.223 INFO ProgressMeter - chr3:187019487 24.5 22998000 939912.6
23:02:17.288 INFO ProgressMeter - chr3:195289841 24.6 23206000 941954.9
23:02:27.347 INFO ProgressMeter - chr3:197509049 24.8 23343000 941111.5
23:02:45.601 INFO ProgressMeter - chr4:41800 25.1 23427000 933053.6
23:02:55.608 INFO ProgressMeter - chr4:10450393 25.3 23750000 939676.1
23:03:05.673 INFO ProgressMeter - chr4:25818220 25.4 23963000 941852.4
23:03:15.685 INFO ProgressMeter - chr4:39556441 25.6 24194000 944735.5
23:03:25.697 INFO ProgressMeter - chr4:49112687 25.8 24389000 946184.7
23:03:35.698 INFO ProgressMeter - chr4:70709942 25.9 24558000 946619.8
23:03:45.726 INFO ProgressMeter - chr4:78840466 26.1 24740000 947530.9
23:03:55.741 INFO ProgressMeter - chr4:84903590 26.3 24897000 947486.8
23:04:05.754 INFO ProgressMeter - chr4:89726325 26.4 25079000 948389.9
23:04:20.758 INFO ProgressMeter - chr4:101300878 26.7 25277000 946922.8
23:04:30.762 INFO ProgressMeter - chr4:112345272 26.9 25617000 953703.5
23:04:40.768 INFO ProgressMeter - chr4:122347615 27.0 25787000 954108.2
23:04:50.811 INFO ProgressMeter - chr4:141301710 27.2 25969000 954928.1
23:05:00.825 INFO ProgressMeter - chr4:148151636 27.4 26118000 954550.0
23:05:10.844 INFO ProgressMeter - chr4:152648160 27.5 26246000 953409.0
23:05:20.903 INFO ProgressMeter - chr4:163545378 27.7 26414000 953703.1
23:05:31.073 INFO ProgressMeter - chr4:177440311 27.9 26573000 953607.9
23:05:41.113 INFO ProgressMeter - chr4:185152116 28.0 26720000 953159.5
23:05:51.864 INFO ProgressMeter - chr5:201335 28.2 26739000 947779.8
23:06:01.880 INFO ProgressMeter - chr5:35863542 28.4 27076000 954079.0
23:06:11.889 INFO ProgressMeter - chr5:39134114 28.5 27267000 955195.1
23:06:21.890 INFO ProgressMeter - chr5:50418852 28.7 27452000 956092.6
23:06:31.914 INFO ProgressMeter - chr5:55014794 28.9 27633000 956829.6
23:06:41.969 INFO ProgressMeter - chr5:62381216 29.0 27810000 957402.3
23:06:51.985 INFO ProgressMeter - chr5:69786348 29.2 27984000 957887.6
23:07:02.045 INFO ProgressMeter - chr5:70477293 29.4 28159000 958378.1
23:07:12.103 INFO ProgressMeter - chr5:71020667 29.5 28309000 958016.9
23:07:22.104 INFO ProgressMeter - chr5:75585375 29.7 28488000 958667.4
23:07:32.113 INFO ProgressMeter - chr5:80142475 29.9 28639000 958368.3
23:07:42.115 INFO ProgressMeter - chr5:82276111 30.0 28724000 955880.4
23:07:52.165 INFO ProgressMeter - chr5:88880504 30.2 28870000 955414.0
23:08:02.217 INFO ProgressMeter - chr5:96742717 30.4 29068000 956662.0
23:08:12.282 INFO ProgressMeter - chr5:100852314 30.6 29195000 955566.2
23:08:22.308 INFO ProgressMeter - chr5:111414442 30.7 29381000 956423.1
23:08:32.332 INFO ProgressMeter - chr5:119129219 30.9 29500000 955102.6
23:08:42.458 INFO ProgressMeter - chr5:126466891 31.1 29602000 953196.7
23:08:52.516 INFO ProgressMeter - chr5:132428179 31.2 29749000 952787.1
23:09:02.523 INFO ProgressMeter - chr5:134927135 31.4 29902000 952599.4
23:09:12.583 INFO ProgressMeter - chr5:140441041 31.6 30053000 952322.6
23:09:22.595 INFO ProgressMeter - chr5:142939724 31.7 30221000 952609.1
23:09:32.621 INFO ProgressMeter - chr5:148882996 31.9 30450000 954798.4
23:09:44.612 INFO ProgressMeter - chr5:150405165 32.1 30525000 951189.4
23:09:54.864 INFO ProgressMeter - chr5:154945350 32.3 30702000 951638.0
23:10:04.969 INFO ProgressMeter - chr5:169654486 32.4 30893000 952585.5
23:10:14.987 INFO ProgressMeter - chr5:170262397 32.6 31064000 952952.1
23:10:25.066 INFO ProgressMeter - chr5:177003095 32.8 31317000 955788.0
23:10:38.549 INFO ProgressMeter - chr5:179579024 33.0 31426000 952582.1
23:10:55.567 INFO ProgressMeter - chr6:81788 33.3 31588000 949330.3
23:11:05.591 INFO ProgressMeter - chr6:16695580 33.4 32095000 959749.1
23:11:15.598 INFO ProgressMeter - chr6:24838396 33.6 32301000 961115.2
23:11:25.673 INFO ProgressMeter - chr6:26411117 33.8 32612000 965545.3
23:11:35.684 INFO ProgressMeter - chr6:29945281 33.9 32774000 965571.3
23:11:45.923 INFO ProgressMeter - chr6:31163221 34.1 32974000 966603.9
23:11:55.994 INFO ProgressMeter - chr6:31354238 34.3 33117000 966042.5
23:12:06.048 INFO ProgressMeter - chr6:31649387 34.4 33249000 965175.7
23:12:16.056 INFO ProgressMeter - chr6:32833435 34.6 33370000 964019.9
23:12:26.077 INFO ProgressMeter - chr6:33276222 34.8 33457000 961892.7
23:12:36.120 INFO ProgressMeter - chr6:36052803 34.9 33614000 961777.6
23:12:46.123 INFO ProgressMeter - chr6:37822079 35.1 33767000 961568.5
23:12:56.125 INFO ProgressMeter - chr6:42209612 35.3 33968000 962722.2
23:13:06.286 INFO ProgressMeter - chr6:43451190 35.5 34069000 960972.8
23:13:16.305 INFO ProgressMeter - chr6:52995630 35.6 34227000 960903.5
23:13:26.321 INFO ProgressMeter - chr6:52995664 35.8 34394000 961087.3
23:13:36.339 INFO ProgressMeter - chr6:52995777 36.0 34762000 966859.5
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23:13:56.409 INFO ProgressMeter - chr6:69737140 36.3 35280000 972221.8
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23:14:36.632 INFO ProgressMeter - chr6:107906095 37.0 35983000 973608.2
23:14:46.665 INFO ProgressMeter - chr6:111663577 37.1 36143000 973532.7
23:14:56.674 INFO ProgressMeter - chr6:116130460 37.3 36223000 971323.0
23:15:06.674 INFO ProgressMeter - chr6:127282468 37.5 36375000 971059.1
23:15:16.719 INFO ProgressMeter - chr6:132755780 37.6 36545000 971257.0
23:15:26.759 INFO ProgressMeter - chr6:141848882 37.8 36707000 971242.7
23:15:36.802 INFO ProgressMeter - chr6:144488784 38.0 36866000 971148.6
23:15:46.828 INFO ProgressMeter - chr6:149398171 38.1 37024000 971036.4
23:15:56.864 INFO ProgressMeter - chr6:153027775 38.3 37121000 969328.1
23:16:06.891 INFO ProgressMeter - chr6:156111016 38.5 37186000 966806.4
23:16:16.955 INFO ProgressMeter - chr6:159036868 38.6 37329000 966310.3
23:16:27.032 INFO ProgressMeter - chr6:160091408 38.8 37497000 966457.4
23:16:37.141 INFO ProgressMeter - chr6:169654972 39.0 37665000 966590.0
23:16:52.672 INFO ProgressMeter - chr7:10523 39.2 37711000 961384.2
23:17:02.693 INFO ProgressMeter - chr7:7256200 39.4 38088000 966878.4
23:17:12.693 INFO ProgressMeter - chr7:23530799 39.6 38297000 968088.1
23:17:22.715 INFO ProgressMeter - chr7:28164027 39.7 38454000 967969.7
23:17:32.719 INFO ProgressMeter - chr7:30633741 39.9 38626000 968235.6
23:17:42.728 INFO ProgressMeter - chr7:36604825 40.1 38783000 968122.8
23:17:52.762 INFO ProgressMeter - chr7:37694564 40.2 38925000 967628.5
23:18:02.793 INFO ProgressMeter - chr7:44058471 40.4 39098000 967906.0
23:18:12.819 INFO ProgressMeter - chr7:50330351 40.6 39239000 967394.8
23:18:22.824 INFO ProgressMeter - chr7:65978476 40.7 39410000 967632.6
23:18:33.073 INFO ProgressMeter - chr7:74097135 40.9 39546000 966916.9
23:18:43.102 INFO ProgressMeter - chr7:75160729 41.1 39623000 964856.4
23:18:53.119 INFO ProgressMeter - chr7:77393557 41.2 39764000 964368.9
23:19:03.132 INFO ProgressMeter - chr7:91992986 41.4 39912000 964056.8
23:19:13.193 INFO ProgressMeter - chr7:98976502 41.6 40052000 963535.4
23:19:23.248 INFO ProgressMeter - chr7:100580845 41.7 40164000 962350.4
23:19:33.393 INFO ProgressMeter - chr7:103094777 41.9 40285000 961354.5
23:19:48.629 INFO ProgressMeter - chr7:106272578 42.2 40506000 960806.1
23:19:58.661 INFO ProgressMeter - chr7:111976608 42.3 40705000 961712.6
23:20:08.691 INFO ProgressMeter - chr7:127767638 42.5 40873000 961882.9
23:20:18.732 INFO ProgressMeter - chr7:130912738 42.7 41017000 961484.7
23:20:28.746 INFO ProgressMeter - chr7:139084013 42.8 41326000 964952.8
23:20:38.761 INFO ProgressMeter - chr7:140454717 43.0 41493000 965090.8
23:20:49.008 INFO ProgressMeter - chr7:142932595 43.2 41661000 965164.4
23:20:59.087 INFO ProgressMeter - chr7:149847894 43.3 41819000 965069.1
23:21:09.097 INFO ProgressMeter - chr7:152031446 43.5 41954000 964471.2
23:21:19.097 INFO ProgressMeter - chr7:157374538 43.7 42090000 963904.5
23:21:31.687 INFO ProgressMeter - chr8:65600 43.9 42121000 960001.3
23:21:41.692 INFO ProgressMeter - chr8:22618422 44.0 42529000 965630.3
23:21:51.719 INFO ProgressMeter - chr8:23567974 44.2 42736000 966662.4
23:22:01.749 INFO ProgressMeter - chr8:27343252 44.4 42961000 968091.2
23:22:11.777 INFO ProgressMeter - chr8:37862597 44.5 43114000 967893.7
23:22:21.841 INFO ProgressMeter - chr8:42416996 44.7 43267000 967684.9
23:22:31.865 INFO ProgressMeter - chr8:55888563 44.9 43421000 967514.1
23:22:41.910 INFO ProgressMeter - chr8:61015704 45.0 43625000 968446.9
23:22:51.935 INFO ProgressMeter - chr8:67338957 45.2 43750000 967632.4
23:23:01.966 INFO ProgressMeter - chr8:80993298 45.4 43924000 967901.9
23:23:12.008 INFO ProgressMeter - chr8:86472394 45.5 43985000 965684.6
23:23:22.016 INFO ProgressMeter - chr8:96899972 45.7 44144000 965639.1
23:23:32.022 INFO ProgressMeter - chr8:100703242 45.9 44319000 965943.5
23:23:42.053 INFO ProgressMeter - chr8:106749581 46.0 44481000 965954.6
23:23:52.098 INFO ProgressMeter - chr8:123080604 46.2 44672000 966588.2
23:24:02.112 INFO ProgressMeter - chr8:127086376 46.4 44791000 965675.7
23:24:12.696 INFO ProgressMeter - chr8:130124100 46.6 44895000 964250.7
23:24:22.720 INFO ProgressMeter - chr8:133534028 46.7 45107000 965340.2
23:24:32.731 INFO ProgressMeter - chr8:142853966 46.9 45264000 965253.4
23:24:42.838 INFO ProgressMeter - chr8:144424072 47.1 45348000 963583.4
23:24:55.179 INFO ProgressMeter - chr9:14084 47.3 45376000 959982.7
23:25:05.199 INFO ProgressMeter - chr9:9442104 47.4 46017000 970116.3
23:25:15.206 INFO ProgressMeter - chr9:9442133 47.6 46621000 979406.0
23:25:26.942 INFO ProgressMeter - chr9:9442163 47.8 47346000 990566.7
23:25:37.104 INFO ProgressMeter - chr9:15856963 48.0 48258000 1006082.1
23:25:48.155 INFO ProgressMeter - chr9:21814893 48.2 48335000 1003832.8
23:25:58.163 INFO ProgressMeter - chr9:34125095 48.3 48574000 1005313.8
23:26:08.219 INFO ProgressMeter - chr9:36136791 48.5 48712000 1004685.0
23:26:18.250 INFO ProgressMeter - chr9:41037315 48.7 48869000 1004459.6
23:26:28.312 INFO ProgressMeter - chr9:68912657 48.8 49056000 1004839.6
23:26:38.363 INFO ProgressMeter - chr9:76493830 49.0 49179000 1003914.6
23:26:49.521 INFO ProgressMeter - chr9:78024591 49.2 49261000 1001785.5
23:26:59.542 INFO ProgressMeter - chr9:86324743 49.3 49439000 1002001.7
23:27:09.563 INFO ProgressMeter - chr9:92964719 49.5 49641000 1002701.6
23:27:19.564 INFO ProgressMeter - chr9:96747998 49.7 49767000 1001873.6
23:27:29.730 INFO ProgressMeter - chr9:104098499 49.8 49894000 1001015.8
23:27:39.740 INFO ProgressMeter - chr9:111897999 50.0 50036000 1000515.9
23:27:49.770 INFO ProgressMeter - chr9:114383713 50.2 50176000 999973.1
23:27:59.772 INFO ProgressMeter - chr9:120456495 50.3 50237000 997873.3
23:28:09.790 INFO ProgressMeter - chr9:123160367 50.5 50384000 997485.0
23:28:19.804 INFO ProgressMeter - chr9:127445155 50.7 50550000 997475.6
23:28:29.836 INFO ProgressMeter - chr9:128751493 50.8 50644000 996044.5
23:28:39.899 INFO ProgressMeter - chr9:131487173 51.0 50757000 994984.6
23:28:49.995 INFO ProgressMeter - chr9:133762979 51.2 50934000 995172.0
23:29:00.040 INFO ProgressMeter - chr9:136823590 51.3 51042000 994030.3
23:29:14.510 INFO ProgressMeter - chr9:137719996 51.6 51082000 990158.9
23:29:24.514 INFO ProgressMeter - chr10:5699964 51.8 51234000 989905.9
23:29:34.518 INFO ProgressMeter - chr10:12749841 51.9 51662000 994970.1
23:29:44.551 INFO ProgressMeter - chr10:21701781 52.1 51888000 996114.8
23:29:54.574 INFO ProgressMeter - chr10:26777168 52.3 52078000 996566.7
23:30:04.602 INFO ProgressMeter - chr10:35547095 52.4 52369000 998940.1
23:30:14.630 INFO ProgressMeter - chr10:45857337 52.6 52575000 999682.5
23:30:24.677 INFO ProgressMeter - chr10:49924674 52.8 52745000 999731.8
23:30:34.713 INFO ProgressMeter - chr10:62027873 52.9 52905000 999595.4
23:30:47.041 INFO ProgressMeter - chr10:68969033 53.1 53024000 997969.5
23:30:57.051 INFO ProgressMeter - chr10:71817361 53.3 53185000 997866.4
23:31:07.090 INFO ProgressMeter - chr10:74205089 53.5 53357000 997960.7
23:31:17.106 INFO ProgressMeter - chr10:84380342 53.6 53566000 998751.4
23:31:27.108 INFO ProgressMeter - chr10:88099743 53.8 53713000 998389.1
23:31:37.164 INFO ProgressMeter - chr10:93675611 54.0 53847000 997771.5
23:31:49.941 INFO ProgressMeter - chr10:96616641 54.2 53941000 995585.1
23:31:59.987 INFO ProgressMeter - chr10:100962780 54.3 54088000 995222.4
23:32:10.053 INFO ProgressMeter - chr10:103438301 54.5 54231000 994782.8
23:32:20.064 INFO ProgressMeter - chr10:112443028 54.7 54377000 994417.4
23:32:30.114 INFO ProgressMeter - chr10:119838683 54.8 54555000 994625.9
23:32:40.137 INFO ProgressMeter - chr10:124990395 55.0 54755000 995241.5
23:32:56.918 INFO ProgressMeter - chr10:132754216 55.3 54875000 992377.5
23:33:06.924 INFO ProgressMeter - chr11:1853083 55.5 55067000 992855.3
23:33:16.929 INFO ProgressMeter - chr11:5225468 55.6 55291000 993905.9
23:33:26.980 INFO ProgressMeter - chr11:5225472 55.8 55485000 994398.8
23:33:37.007 INFO ProgressMeter - chr11:5225492 56.0 55678000 994878.0
23:33:47.037 INFO ProgressMeter - chr11:5225493 56.1 55871000 995353.5
23:33:57.058 INFO ProgressMeter - chr11:5225499 56.3 56064000 995828.8
23:34:07.088 INFO ProgressMeter - chr11:5225528 56.5 56257000 996298.7
23:34:17.110 INFO ProgressMeter - chr11:5225536 56.6 56439000 996573.8
23:34:27.118 INFO ProgressMeter - chr11:5225540 56.8 56610000 996657.9
23:34:40.501 INFO ProgressMeter - chr11:5225545 57.0 56763000 995442.8
23:34:50.526 INFO ProgressMeter - chr11:5225554 57.2 56947000 995751.6
23:35:00.530 INFO ProgressMeter - chr11:5225566 57.4 57132000 996082.4
23:35:10.549 INFO ProgressMeter - chr11:5225579 57.5 57314000 996354.8
23:35:20.552 INFO ProgressMeter - chr11:5225580 57.7 57708000 1000305.1
23:35:30.561 INFO ProgressMeter - chr11:5225582 57.9 58086000 1003954.3
23:35:48.833 INFO ProgressMeter - chr11:5225600 58.2 58688000 1009048.0
23:35:58.833 INFO ProgressMeter - chr11:5225626 58.3 59303000 1016708.6
23:36:15.138 INFO ProgressMeter - chr11:5225645 58.6 59687000 1018546.6
23:36:25.139 INFO ProgressMeter - chr11:5225657 58.8 60150000 1023536.2
23:36:38.248 INFO ProgressMeter - chr11:5225659 59.0 60360000 1023305.5
23:36:48.257 INFO ProgressMeter - chr11:5225665 59.2 60750000 1027012.5
23:37:00.841 INFO ProgressMeter - chr11:5225668 59.4 60957000 1026871.1
23:37:10.855 INFO ProgressMeter - chr11:5225671 59.5 61305000 1029837.9
23:37:21.865 INFO ProgressMeter - chr11:5225672 59.7 61504000 1030005.8
23:37:31.887 INFO ProgressMeter - chr11:5225690 59.9 61929000 1034230.2
23:37:42.497 INFO ProgressMeter - chr11:5225695 60.1 62145000 1034781.6
23:37:52.526 INFO ProgressMeter - chr11:5225713 60.2 62526000 1038236.0
23:38:03.298 INFO ProgressMeter - chr11:5225724 60.4 62706000 1038130.1
23:38:13.299 INFO ProgressMeter - chr11:5226590 60.6 63133000 1042323.3
23:38:26.328 INFO ProgressMeter - chr11:5226598 60.8 63516000 1044900.2
23:38:36.339 INFO ProgressMeter - chr11:5226609 61.0 64104000 1051686.7
23:38:48.596 INFO ProgressMeter - chr11:5226628 61.2 64454000 1053896.6
23:38:58.612 INFO ProgressMeter - chr11:5226648 61.3 64966000 1059376.8
23:39:13.342 INFO ProgressMeter - chr11:5226655 61.6 65255000 1059846.6
23:39:23.354 INFO ProgressMeter - chr11:5226677 61.7 65738000 1064805.4
23:39:37.456 INFO ProgressMeter - chr11:5226693 62.0 66119000 1066915.0
23:39:47.459 INFO ProgressMeter - chr11:5226721 62.1 66637000 1072388.7
23:39:57.477 INFO ProgressMeter - chr11:5226731 62.3 66942000 1074410.1
23:40:07.510 INFO ProgressMeter - chr11:5226733 62.5 67015000 1072702.8
23:40:17.543 INFO ProgressMeter - chr11:5226755 62.6 67358000 1075315.0
23:40:35.132 INFO ProgressMeter - chr11:5226770 62.9 67539000 1073182.1
23:40:45.132 INFO ProgressMeter - chr11:5226932 63.1 67844000 1075181.1
23:40:57.214 INFO ProgressMeter - chr11:5226955 63.3 68281000 1078664.4
23:41:07.216 INFO ProgressMeter - chr11:5226966 63.5 68432000 1078210.4
23:41:17.236 INFO ProgressMeter - chr11:5226981 63.6 68884000 1082483.8
23:41:27.261 INFO ProgressMeter - chr11:6604269 63.8 69248000 1085354.4
23:41:37.261 INFO ProgressMeter - chr11:8682814 64.0 69305000 1083417.7
23:41:47.303 INFO ProgressMeter - chr11:13312140 64.1 69518000 1083911.5
23:41:57.316 INFO ProgressMeter - chr11:17949095 64.3 69668000 1083430.9
23:42:07.355 INFO ProgressMeter - chr11:33350133 64.5 69791000 1082527.2
23:42:17.412 INFO ProgressMeter - chr11:44115400 64.6 69981000 1082659.2
23:42:27.472 INFO ProgressMeter - chr11:47168981 64.8 70101000 1081710.1
23:42:43.303 INFO ProgressMeter - chr11:47991348 65.1 70170000 1078384.0
23:42:53.387 INFO ProgressMeter - chr11:60380740 65.2 70348000 1078334.4
23:43:03.391 INFO ProgressMeter - chr11:62526869 65.4 70504000 1077970.8
23:43:13.480 INFO ProgressMeter - chr11:64308269 65.6 70665000 1077661.9
23:43:23.505 INFO ProgressMeter - chr11:65425368 65.7 70764000 1076428.5
23:43:33.520 INFO ProgressMeter - chr11:65502935 65.9 71017000 1077541.1
23:43:43.532 INFO ProgressMeter - chr11:65503725 66.1 71100000 1076076.3
23:43:53.557 INFO ProgressMeter - chr11:65505569 66.2 71340000 1076984.9
23:44:03.612 INFO ProgressMeter - chr11:66244048 66.4 71518000 1076947.5
23:44:13.697 INFO ProgressMeter - chr11:68006477 66.6 71631000 1075926.1
23:44:23.769 INFO ProgressMeter - chr11:72027926 66.7 71736000 1074793.0
23:44:33.784 INFO ProgressMeter - chr11:73402090 66.9 71851000 1073830.8
23:44:43.849 INFO ProgressMeter - chr11:75798515 67.1 71988000 1073187.4
23:44:53.891 INFO ProgressMeter - chr11:76531923 67.2 72027000 1071096.4
23:45:03.915 INFO ProgressMeter - chr11:85967762 67.4 72200000 1071008.2
23:45:13.936 INFO ProgressMeter - chr11:94219076 67.6 72345000 1070506.9
23:45:23.975 INFO ProgressMeter - chr11:104944823 67.7 72551000 1070903.8
23:45:33.998 INFO ProgressMeter - chr11:111352853 67.9 72693000 1070360.5
23:45:44.131 INFO ProgressMeter - chr11:117285899 68.1 72811000 1069438.6
23:46:00.117 INFO ProgressMeter - chr11:118751841 68.3 72940000 1067157.2
23:46:10.172 INFO ProgressMeter - chr11:121550631 68.5 73109000 1067013.6
23:46:20.268 INFO ProgressMeter - chr11:123738415 68.7 73293000 1067078.8
23:46:30.286 INFO ProgressMeter - chr11:128772858 68.9 73492000 1067381.1
23:46:50.467 INFO ProgressMeter - chr12:14889 69.2 73595000 1063680.9
23:47:00.473 INFO ProgressMeter - chr12:9021388 69.4 73981000 1066688.8
23:47:10.473 INFO ProgressMeter - chr12:10315620 69.5 74216000 1067511.8
23:47:20.552 INFO ProgressMeter - chr12:14795862 69.7 74482000 1068755.5
23:47:30.579 INFO ProgressMeter - chr12:26921218 69.9 74674000 1068947.2
23:47:40.645 INFO ProgressMeter - chr12:32721875 70.0 74876000 1069270.9
23:47:50.725 INFO ProgressMeter - chr12:43783713 70.2 75043000 1069090.9
23:48:00.737 INFO ProgressMeter - chr12:48153400 70.4 75249000 1069483.2
23:48:10.765 INFO ProgressMeter - chr12:50725118 70.5 75381000 1068820.7
23:48:20.926 INFO ProgressMeter - chr12:53009617 70.7 75451000 1067250.5
23:48:31.008 INFO ProgressMeter - chr12:55805371 70.9 75624000 1067160.9
23:48:41.038 INFO ProgressMeter - chr12:57190863 71.0 75751000 1066437.6
23:48:51.039 INFO ProgressMeter - chr12:62563054 71.2 75931000 1066468.8
23:49:01.095 INFO ProgressMeter - chr12:68435534 71.4 76110000 1066472.7
23:49:13.113 INFO ProgressMeter - chr12:75503102 71.6 76303000 1066184.4
23:49:23.135 INFO ProgressMeter - chr12:89695312 71.7 76505000 1066517.8
23:49:33.193 INFO ProgressMeter - chr12:95998725 71.9 76685000 1066534.9
23:49:43.409 INFO ProgressMeter - chr12:102378362 72.1 76803000 1065652.3
23:49:53.445 INFO ProgressMeter - chr12:104688816 72.2 76954000 1065275.1
23:50:03.479 INFO ProgressMeter - chr12:108801771 72.4 77120000 1065107.3
23:50:13.616 INFO ProgressMeter - chr12:111406754 72.6 77222000 1064033.2
23:50:23.677 INFO ProgressMeter - chr12:112153226 72.7 77267000 1062199.1
23:50:33.760 INFO ProgressMeter - chr12:116851282 72.9 77443000 1062164.8
23:50:43.871 INFO ProgressMeter - chr12:121229841 73.1 77604000 1061918.6
23:50:53.938 INFO ProgressMeter - chr12:123320497 73.2 77701000 1060810.4
23:51:03.962 INFO ProgressMeter - chr12:124913095 73.4 77853000 1060466.8
23:51:13.987 INFO ProgressMeter - chr12:132741496 73.6 77985000 1059852.6
23:51:28.111 INFO ProgressMeter - chr13:18299235 73.8 78011000 1056825.0
23:51:38.138 INFO ProgressMeter - chr13:34981885 74.0 78395000 1059628.2
23:51:48.188 INFO ProgressMeter - chr13:45340036 74.2 78639000 1060525.1
23:51:58.215 INFO ProgressMeter - chr13:48256451 74.3 78832000 1060737.3
23:52:08.246 INFO ProgressMeter - chr13:51594115 74.5 79017000 1060840.2
23:52:18.284 INFO ProgressMeter - chr13:75648283 74.7 79220000 1061182.1
23:52:28.305 INFO ProgressMeter - chr13:98548312 74.8 79373000 1060858.1
23:52:38.324 INFO ProgressMeter - chr13:109511479 75.0 79529000 1060576.2
23:52:48.392 INFO ProgressMeter - chr13:113974334 75.2 79665000 1060017.8
23:52:59.892 INFO ProgressMeter - chr14:18461140 75.3 79702000 1057812.4
23:53:09.926 INFO ProgressMeter - chr14:30712189 75.5 80152000 1061428.9
23:53:19.965 INFO ProgressMeter - chr14:49538789 75.7 80355000 1061764.6
23:53:30.012 INFO ProgressMeter - chr14:49543275 75.8 80563000 1062162.9
23:53:40.032 INFO ProgressMeter - chr14:49572997 76.0 80769000 1062539.4
23:53:50.044 INFO ProgressMeter - chr14:49581951 76.2 80924000 1062246.6
23:54:00.084 INFO ProgressMeter - chr14:49586588 76.3 81104000 1062276.1
23:54:14.607 INFO ProgressMeter - chr14:49586599 76.6 81479000 1063815.1
23:54:24.608 INFO ProgressMeter - chr14:49586637 76.8 82131000 1069999.5
23:54:35.164 INFO ProgressMeter - chr14:49586651 76.9 82455000 1071763.7
23:54:45.174 INFO ProgressMeter - chr14:49586680 77.1 83136000 1078277.2
23:54:57.112 INFO ProgressMeter - chr14:49586682 77.3 83442000 1079460.4
23:55:07.112 INFO ProgressMeter - chr14:49586684 77.5 84123000 1085928.9
23:55:21.209 INFO ProgressMeter - chr14:49586685 77.7 84442000 1086750.7
23:55:31.222 INFO ProgressMeter - chr14:49586710 77.9 85119000 1093115.8
23:55:46.368 INFO ProgressMeter - chr14:49586715 78.1 85442000 1093718.3
23:55:56.381 INFO ProgressMeter - chr14:49586774 78.3 86095000 1099727.9
23:56:11.978 INFO ProgressMeter - chr14:49853688 78.5 86377000 1099678.8
23:56:25.172 INFO ProgressMeter - chr14:49862569 78.8 87200000 1107057.0
23:56:35.700 INFO ProgressMeter - chr14:49862575 78.9 87279000 1105597.0
23:56:45.702 INFO ProgressMeter - chr14:49862644 79.1 88248000 1115516.4
23:56:55.707 INFO ProgressMeter - chr14:49862648 79.3 88367000 1114670.9
23:57:15.170 INFO ProgressMeter - chr14:49862671 79.6 89258000 1121321.8
23:57:25.171 INFO ProgressMeter - chr14:49862684 79.8 90222000 1131063.8
23:57:36.330 INFO ProgressMeter - chr14:49862687 80.0 90258000 1128883.0
23:57:46.336 INFO ProgressMeter - chr14:49862721 80.1 91248000 1138889.8
23:57:57.594 INFO ProgressMeter - chr14:49862721 80.3 91253000 1136291.1
23:58:08.818 INFO ProgressMeter - chr14:49862763 80.5 91995000 1142868.4
23:58:21.421 INFO ProgressMeter - chr14:49862768 80.7 92253000 1143090.7
23:58:31.454 INFO ProgressMeter - chr14:55055287 80.9 92494000 1143707.2
23:58:41.460 INFO ProgressMeter - chr14:60109152 81.0 92644000 1143204.5
23:58:51.496 INFO ProgressMeter - chr14:64220448 81.2 92832000 1143164.9
23:59:01.546 INFO ProgressMeter - chr14:67648627 81.4 92941000 1142151.5
23:59:11.569 INFO ProgressMeter - chr14:70973326 81.5 93134000 1142178.3
23:59:24.475 INFO ProgressMeter - chr14:71361437 81.8 93186000 1139809.3
23:59:34.513 INFO ProgressMeter - chr14:74673792 81.9 93340000 1139361.4
23:59:44.546 INFO ProgressMeter - chr14:81494935 82.1 93466000 1138575.4
23:59:54.555 INFO ProgressMeter - chr14:90971436 82.3 93619000 1138126.4
00:00:04.600 INFO ProgressMeter - chr14:92980158 82.4 93784000 1137816.6
00:00:14.612 INFO ProgressMeter - chr14:96554695 82.6 93925000 1137225.2
00:00:24.648 INFO ProgressMeter - chr14:101829946 82.8 94094000 1136968.8
00:00:34.780 INFO ProgressMeter - chr14:101991602 82.9 94127000 1135051.2
00:00:44.937 INFO ProgressMeter - chr14:105155748 83.1 94267000 1134423.7
00:00:58.717 INFO ProgressMeter - chr15:20118463 83.3 94330000 1132053.1
00:01:08.756 INFO ProgressMeter - chr15:38508472 83.5 94636000 1133449.4
00:01:18.821 INFO ProgressMeter - chr15:43396097 83.7 94812000 1133280.5
00:01:28.854 INFO ProgressMeter - chr15:44717658 83.8 94977000 1132988.2
00:01:38.940 INFO ProgressMeter - chr15:51494282 84.0 95152000 1132804.2
00:01:48.958 INFO ProgressMeter - chr15:58150338 84.2 95352000 1132933.2
00:01:59.064 INFO ProgressMeter - chr15:61954338 84.3 95540000 1132899.7
00:02:09.083 INFO ProgressMeter - chr15:64327953 84.5 95686000 1132388.7
00:02:19.115 INFO ProgressMeter - chr15:67738659 84.7 95847000 1132054.1
00:02:29.228 INFO ProgressMeter - chr15:73219232 84.8 96018000 1131820.8
00:02:39.232 INFO ProgressMeter - chr15:76765352 85.0 96143000 1131071.1
00:02:49.271 INFO ProgressMeter - chr15:78934624 85.2 96214000 1129682.7
00:02:59.290 INFO ProgressMeter - chr15:85671103 85.3 96416000 1129839.3
00:03:09.297 INFO ProgressMeter - chr15:90501158 85.5 96596000 1129740.8
00:03:19.319 INFO ProgressMeter - chr15:93014789 85.7 96756000 1129405.5
00:03:29.335 INFO ProgressMeter - chr15:101646822 85.8 96979000 1129807.0
00:03:41.691 INFO ProgressMeter - chr16:11885 86.0 96998000 1127323.8
00:03:54.690 INFO ProgressMeter - chr16:172892 86.3 98977000 1147434.8
00:04:06.134 INFO ProgressMeter - chr16:172915 86.5 99950000 1156158.3
00:04:19.431 INFO ProgressMeter - chr16:172951 86.7 100743000 1162351.5
00:04:34.201 INFO ProgressMeter - chr16:172972 86.9 101431000 1166975.0
00:04:46.875 INFO ProgressMeter - chr16:172975 87.1 101969000 1170320.6
00:04:59.438 INFO ProgressMeter - chr16:173007 87.3 102728000 1176205.2
00:05:12.647 INFO ProgressMeter - chr16:173167 87.6 103686000 1184189.1
00:05:27.032 INFO ProgressMeter - chr16:173193 87.8 104624000 1191639.0
00:05:43.909 INFO ProgressMeter - chr16:173226 88.1 105456000 1197279.5
00:05:59.067 INFO ProgressMeter - chr16:173250 88.3 106453000 1205142.2
00:06:09.557 INFO ProgressMeter - chr16:173261 88.5 107207000 1211280.7
00:06:19.559 INFO ProgressMeter - chr16:173263 88.7 107262000 1209623.8
00:06:36.738 INFO ProgressMeter - chr16:173278 89.0 107866000 1212520.2
00:06:53.612 INFO ProgressMeter - chr16:173290 89.2 108531000 1216150.8
00:07:04.275 INFO ProgressMeter - chr16:173299 89.4 108999000 1218967.5
00:07:14.275 INFO ProgressMeter - chr16:173300 89.6 109185000 1218776.0
00:07:26.789 INFO ProgressMeter - chr16:173313 89.8 109625000 1220845.2
00:07:41.758 INFO ProgressMeter - chr16:173327 90.0 110262000 1224536.9
00:07:51.764 INFO ProgressMeter - chr16:173474 90.2 110916000 1229522.9
00:08:01.769 INFO ProgressMeter - chr16:173488 90.4 111335000 1231890.7
00:08:18.681 INFO ProgressMeter - chr16:173505 90.7 111902000 1234314.7
00:08:36.214 INFO ProgressMeter - chr16:173516 91.0 112792000 1240134.4
00:08:46.223 INFO ProgressMeter - chr16:173530 91.1 113565000 1246347.5
00:08:57.272 INFO ProgressMeter - chr16:173534 91.3 113731000 1245652.0
00:09:07.274 INFO ProgressMeter - chr16:173546 91.5 114331000 1249941.2
00:09:19.333 INFO ProgressMeter - chr16:173552 91.7 114631000 1250473.4
00:09:29.510 INFO ProgressMeter - chr16:173583 91.8 115175000 1254087.3
00:09:42.138 INFO ProgressMeter - chr16:173585 92.1 115431000 1254001.0
00:09:54.569 INFO ProgressMeter - chr16:173588 92.3 116140000 1258869.9
00:10:04.570 INFO ProgressMeter - chr16:173589 92.4 116221000 1257476.0
00:10:17.116 INFO ProgressMeter - chr16:173625 92.6 116774000 1260607.3
00:10:28.537 INFO ProgressMeter - chr16:176694 92.8 117060000 1261103.5
00:10:42.830 INFO ProgressMeter - chr16:176729 93.1 118045000 1268459.5
00:10:58.441 INFO ProgressMeter - chr16:176770 93.3 118957000 1274695.7
00:11:16.004 INFO ProgressMeter - chr16:176778 93.6 119893000 1280708.4
00:11:34.001 INFO ProgressMeter - chr16:176793 93.9 120775000 1286009.5
00:11:44.013 INFO ProgressMeter - chr16:176811 94.1 121091000 1287087.6
00:11:56.627 INFO ProgressMeter - chr16:176958 94.3 121569000 1289287.0
00:12:12.376 INFO ProgressMeter - chr16:176992 94.6 122565000 1296241.6
00:12:30.594 INFO ProgressMeter - chr16:177013 94.9 123565000 1302634.5
00:12:44.578 INFO ProgressMeter - chr16:177061 95.1 124564000 1309947.5
00:12:57.838 INFO ProgressMeter - chr16:177091 95.3 125541000 1317160.7
00:13:11.388 INFO ProgressMeter - chr16:177103 95.5 126526000 1324357.2
00:13:26.965 INFO ProgressMeter - chr16:177121 95.8 127487000 1330799.7
00:13:45.062 INFO ProgressMeter - chr16:177285 96.1 128340000 1335499.2
00:13:59.909 INFO ProgressMeter - chr16:177322 96.3 129308000 1342116.2
00:14:14.557 INFO ProgressMeter - chr16:177342 96.6 130308000 1349077.0
00:14:30.715 INFO ProgressMeter - chr16:177395 96.9 131308000 1355650.4
00:14:45.429 INFO ProgressMeter - chr16:177411 97.1 132308000 1362524.9
00:14:55.432 INFO ProgressMeter - chr16:1938264 97.3 132734000 1364569.1
00:15:05.618 INFO ProgressMeter - chr16:3044240 97.4 132835000 1363228.2
00:15:15.718 INFO ProgressMeter - chr16:4859869 97.6 132967000 1362229.8
00:15:25.741 INFO ProgressMeter - chr16:11581936 97.8 133119000 1361456.8
00:15:42.551 INFO ProgressMeter - chr16:14482482 98.1 133238000 1358780.4
00:15:52.555 INFO ProgressMeter - chr16:18358230 98.2 133366000 1357777.1
00:16:02.587 INFO ProgressMeter - chr16:21626864 98.4 133507000 1356902.8
00:16:12.605 INFO ProgressMeter - chr16:23838314 98.6 133672000 1356278.2
00:16:22.637 INFO ProgressMeter - chr16:27635161 98.7 133856000 1355845.0
00:16:32.884 INFO ProgressMeter - chr16:28985731 98.9 133996000 1354919.2
00:16:42.935 INFO ProgressMeter - chr16:29833986 99.1 134123000 1353910.0
00:16:54.560 INFO ProgressMeter - chr16:30092430 99.3 134158000 1351620.1
00:17:04.596 INFO ProgressMeter - chr16:31276688 99.4 134311000 1350884.8
00:17:14.644 INFO ProgressMeter - chr16:48567943 99.6 134451000 1350019.0
00:17:24.653 INFO ProgressMeter - chr16:55531239 99.8 134622000 1349475.6
00:17:34.824 INFO ProgressMeter - chr16:58518754 99.9 134725000 1348217.3
00:17:44.925 INFO ProgressMeter - chr16:67656863 100.1 134825000 1346948.6
00:17:54.929 INFO ProgressMeter - chr16:69696672 100.3 134934000 1345795.8
00:18:04.954 INFO ProgressMeter - chr16:71927839 100.4 135027000 1344482.9
00:18:16.269 INFO ProgressMeter - chr16:74324522 100.6 135049000 1342181.9
00:18:26.273 INFO ProgressMeter - chr16:83901225 100.8 135253000 1341985.4
00:18:36.307 INFO ProgressMeter - chr16:88062416 101.0 135393000 1341149.1
00:18:46.565 INFO ProgressMeter - chr16:89871808 101.1 135513000 1340068.3
00:19:01.515 INFO ProgressMeter - chr17:61561 101.4 135587000 1337504.5
00:19:11.530 INFO ProgressMeter - chr17:5539453 101.5 135903000 1338417.9
00:19:21.549 INFO ProgressMeter - chr17:8925265 101.7 136090000 1338059.1
00:19:31.599 INFO ProgressMeter - chr17:16429565 101.9 136340000 1338313.1
00:19:41.602 INFO ProgressMeter - chr17:21013996 102.0 136507000 1337763.1
00:19:51.652 INFO ProgressMeter - chr17:29095897 102.2 136660000 1337067.7
00:20:01.669 INFO ProgressMeter - chr17:30466991 102.4 136819000 1336440.4
00:20:11.735 INFO ProgressMeter - chr17:35368118 102.5 136963000 1335658.2
00:20:21.741 INFO ProgressMeter - chr17:38238319 102.7 137138000 1335193.4
00:20:31.756 INFO ProgressMeter - chr17:40328085 102.9 137282000 1334427.0
00:20:42.491 INFO ProgressMeter - chr17:42274555 103.1 137365000 1332915.4
00:20:52.529 INFO ProgressMeter - chr17:44262700 103.2 137527000 1332324.5
00:21:02.588 INFO ProgressMeter - chr17:45396935 103.4 137693000 1331769.7
00:21:12.685 INFO ProgressMeter - chr17:47660033 103.6 137886000 1331469.2
00:21:22.815 INFO ProgressMeter - chr17:50133926 103.7 138060000 1330979.5
00:21:32.834 INFO ProgressMeter - chr17:58001227 103.9 138200000 1330187.9
00:21:42.864 INFO ProgressMeter - chr17:59646919 104.1 138252000 1328550.7
00:21:52.933 INFO ProgressMeter - chr17:63238776 104.2 138439000 1328205.8
00:22:02.939 INFO ProgressMeter - chr17:64772044 104.4 138602000 1327645.4
00:22:13.047 INFO ProgressMeter - chr17:69319606 104.6 138804000 1327438.2
00:22:23.062 INFO ProgressMeter - chr17:75488773 104.7 138944000 1326659.6
00:22:33.204 INFO ProgressMeter - chr17:76480675 104.9 139026000 1325303.3
00:22:44.919 INFO ProgressMeter - chr17:77488811 105.1 139111000 1323650.0
00:22:54.978 INFO ProgressMeter - chr17:80325160 105.3 139280000 1323147.3
00:23:04.988 INFO ProgressMeter - chr17:81888559 105.4 139427000 1322447.9
00:23:21.528 INFO ProgressMeter - chr18:102375 105.7 139506000 1319746.5
00:23:31.545 INFO ProgressMeter - chr18:21669289 105.9 139954000 1321896.8
00:23:41.562 INFO ProgressMeter - chr18:37085742 106.0 140134000 1321513.1
00:23:51.599 INFO ProgressMeter - chr18:50914571 106.2 140312000 1321107.6
00:24:01.636 INFO ProgressMeter - chr18:63263395 106.4 140484000 1320647.0
00:24:11.666 INFO ProgressMeter - chr18:77051123 106.5 140709000 1320686.9
00:24:22.821 INFO ProgressMeter - chr19:60699 106.7 140817000 1319398.0
00:24:32.834 INFO ProgressMeter - chr19:3177925 106.9 141167000 1320612.5
00:24:42.875 INFO ProgressMeter - chr19:6221668 107.1 141356000 1320313.5
00:24:53.021 INFO ProgressMeter - chr19:9425170 107.2 141494000 1319518.4
00:25:03.058 INFO ProgressMeter - chr19:11576560 107.4 141628000 1318711.0
00:25:13.062 INFO ProgressMeter - chr19:14574659 107.6 141766000 1317949.6
00:25:23.097 INFO ProgressMeter - chr19:17275190 107.7 141908000 1317221.7
00:25:33.156 INFO ProgressMeter - chr19:18538413 107.9 142047000 1316463.3
00:25:43.366 INFO ProgressMeter - chr19:19660067 108.1 142176000 1315584.2
00:25:53.445 INFO ProgressMeter - chr19:33815388 108.2 142321000 1314881.9
00:26:03.469 INFO ProgressMeter - chr19:36234582 108.4 142417000 1313741.1
00:26:13.471 INFO ProgressMeter - chr19:38417167 108.6 142471000 1312221.4
00:26:23.582 INFO ProgressMeter - chr19:41397247 108.7 142608000 1311447.7
00:26:33.688 INFO ProgressMeter - chr19:45059314 108.9 142721000 1310457.2
00:26:43.689 INFO ProgressMeter - chr19:48220742 109.1 142835000 1309499.8
00:26:53.692 INFO ProgressMeter - chr19:49497550 109.2 143047000 1309441.8
00:27:03.790 INFO ProgressMeter - chr19:51644017 109.4 143138000 1308259.3
00:27:13.901 INFO ProgressMeter - chr19:54173657 109.6 143252000 1307287.7
00:27:23.945 INFO ProgressMeter - chr19:54596234 109.7 143315000 1305867.7
00:27:33.953 INFO ProgressMeter - chr19:58393094 109.9 143449000 1305105.1
00:27:43.973 INFO ProgressMeter - chr20:3800573 110.1 143669000 1305123.9
00:27:53.979 INFO ProgressMeter - chr20:18517085 110.2 143940000 1305607.8
00:28:04.027 INFO ProgressMeter - chr20:32460536 110.4 144227000 1306226.7
00:28:14.055 INFO ProgressMeter - chr20:35869551 110.6 144388000 1305708.4
00:28:24.077 INFO ProgressMeter - chr20:41489965 110.7 144556000 1305256.1
00:28:34.108 INFO ProgressMeter - chr20:45952705 110.9 144701000 1304596.0
00:28:44.114 INFO ProgressMeter - chr20:48809208 111.1 144873000 1304186.0
00:28:54.139 INFO ProgressMeter - chr20:53582471 111.3 145073000 1304024.8
00:29:04.167 INFO ProgressMeter - chr20:58909747 111.4 145219000 1303379.1
00:29:14.244 INFO ProgressMeter - chr20:62807519 111.6 145330000 1302412.1
00:29:26.209 INFO ProgressMeter - chr21:5023620 111.8 145411000 1300813.3
00:29:36.211 INFO ProgressMeter - chr21:8259401 112.0 147036000 1313391.5
00:29:48.404 INFO ProgressMeter - chr21:8397347 112.2 147818000 1317984.3
00:29:58.405 INFO ProgressMeter - chr21:8441389 112.3 148424000 1321423.6
00:30:13.193 INFO ProgressMeter - chr21:15777849 112.6 149407000 1327262.9
00:30:23.254 INFO ProgressMeter - chr21:33528280 112.7 149667000 1327595.0
00:30:33.274 INFO ProgressMeter - chr21:37231191 112.9 149853000 1327278.7
00:30:43.329 INFO ProgressMeter - chr21:41325911 113.1 150048000 1327036.2
00:30:53.343 INFO ProgressMeter - chr21:44327095 113.2 150156000 1326034.0
00:31:03.554 INFO ProgressMeter - chr21:46322359 113.4 150254000 1324908.2
00:31:21.367 INFO ProgressMeter - chr22:10767913 113.7 150284000 1321712.9
00:31:31.413 INFO ProgressMeter - chr22:24543098 113.9 150622000 1322737.6
00:31:41.437 INFO ProgressMeter - chr22:30027591 114.0 150827000 1322597.4
00:31:51.457 INFO ProgressMeter - chr22:32493196 114.2 150999000 1322169.4
00:32:01.492 INFO ProgressMeter - chr22:36926073 114.4 151171000 1321739.9
00:32:11.553 INFO ProgressMeter - chr22:38495909 114.5 151355000 1321411.3
00:32:21.612 INFO ProgressMeter - chr22:40804027 114.7 151552000 1321197.6
00:32:31.614 INFO ProgressMeter - chr22:43929689 114.9 151716000 1320707.8
00:32:41.651 INFO ProgressMeter - chr22:50220326 115.0 151894000 1320334.6
00:32:55.186 INFO ProgressMeter - chrX:290691 115.3 151933000 1318089.0
00:33:05.201 INFO ProgressMeter - chrX:24204590 115.4 152353000 1319821.7
00:33:15.253 INFO ProgressMeter - chrX:45089837 115.6 152580000 1319872.4
00:33:25.307 INFO ProgressMeter - chrX:53551277 115.8 152745000 1319387.4
00:33:35.316 INFO ProgressMeter - chrX:56184763 115.9 152909000 1318903.6
00:33:45.342 INFO ProgressMeter - chrX:71536300 116.1 153117000 1318796.7
00:33:55.356 INFO ProgressMeter - chrX:78281634 116.3 153431000 1319604.4
00:34:05.411 INFO ProgressMeter - chrX:102780922 116.4 153569000 1318890.2
00:34:15.418 INFO ProgressMeter - chrX:118452761 116.6 153706000 1318178.6
00:34:25.426 INFO ProgressMeter - chrX:120455475 116.8 153813000 1317212.0
00:34:35.435 INFO ProgressMeter - chrX:135540593 116.9 153968000 1316658.7
00:34:45.530 INFO ProgressMeter - chrX:151406122 117.1 154099000 1315885.4
00:34:55.728 INFO ProgressMeter - chrX:154467977 117.3 154220000 1315010.1
00:35:09.774 INFO ProgressMeter - chrY:300240 117.5 154318000 1313224.3
00:35:17.957 INFO SplitNCigarReads - 0 read(s) filtered by: AllowAllReadsReadFilter
00:35:27.075 INFO OverhangFixingManager - Overhang Fixing Manager saved 38946 reads in the first pass
00:35:27.080 INFO SplitNCigarReads - Starting traversal pass 2
00:35:27.094 INFO ProgressMeter - chr1:14714 117.8 155708000 1321806.0
00:35:37.115 INFO ProgressMeter - chr1:8388824 118.0 156135000 1323554.5
00:35:47.130 INFO ProgressMeter - chr1:12208452 118.1 156307000 1323140.1
00:35:57.161 INFO ProgressMeter - chr1:17359744 118.3 156468000 1322631.2
00:36:07.200 INFO ProgressMeter - chr1:21727163 118.5 156637000 1322189.8
00:36:17.237 INFO ProgressMeter - chr1:25335453 118.6 156794000 1321648.8
00:36:27.241 INFO ProgressMeter - chr1:27613226 118.8 156952000 1321123.8
00:36:37.248 INFO ProgressMeter - chr1:29118574 119.0 157135000 1320810.1
00:36:47.313 INFO ProgressMeter - chr1:32949653 119.1 157292000 1320268.0
00:36:57.394 INFO ProgressMeter - chr1:36358250 119.3 157435000 1319607.3
00:37:12.196 INFO ProgressMeter - chr1:36475956 119.6 157495000 1317386.3
00:37:22.200 INFO ProgressMeter - chr1:40072163 119.7 157641000 1316771.1
00:37:32.210 INFO ProgressMeter - chr1:42696790 119.9 157816000 1316398.2
00:37:42.244 INFO ProgressMeter - chr1:45686443 120.1 157925000 1315472.4
00:37:52.365 INFO ProgressMeter - chr1:52313707 120.2 158062000 1314766.2
00:38:02.405 INFO ProgressMeter - chr1:55172497 120.4 158160000 1313752.7
00:38:12.424 INFO ProgressMeter - chr1:64872839 120.6 158274000 1312878.7
00:38:32.153 INFO ProgressMeter - chr1:67424222 120.9 158383000 1310209.2
00:38:42.170 INFO ProgressMeter - chr1:87384343 121.1 158601000 1310203.3
00:38:52.181 INFO ProgressMeter - chr1:90000472 121.2 158789000 1309950.6
00:39:02.198 INFO ProgressMeter - chr1:97141181 121.4 158930000 1309310.5
00:39:12.339 INFO ProgressMeter - chr1:100271793 121.6 159086000 1308773.3
00:39:22.472 INFO ProgressMeter - chr1:109188200 121.7 159237000 1308198.0
00:39:44.602 INFO ProgressMeter - chr1:110895271 122.1 159321000 1304934.0
00:39:54.689 INFO ProgressMeter - chr1:114464833 122.3 159491000 1304530.3
00:40:04.724 INFO ProgressMeter - chr1:119157855 122.4 159675000 1304251.1
00:40:14.775 INFO ProgressMeter - chr1:120524039 122.6 159847000 1303871.7
00:40:24.818 INFO ProgressMeter - chr1:120997461 122.8 159991000 1303266.9
00:40:34.820 INFO ProgressMeter - chr1:145394018 122.9 160231000 1303451.9
00:40:53.203 INFO ProgressMeter - chr1:145992881 123.2 160279000 1300600.8
00:41:03.206 INFO ProgressMeter - chr1:146260118 123.4 160474000 1300424.1
00:41:13.219 INFO ProgressMeter - chr1:148652577 123.6 160664000 1300205.2
00:41:23.249 INFO ProgressMeter - chr1:149616329 123.7 160884000 1300226.7
00:41:33.265 INFO ProgressMeter - chr1:150575602 123.9 161018000 1299556.4
00:41:43.309 INFO ProgressMeter - chr1:151167608 124.1 161178000 1299092.5
00:42:01.548 INFO ProgressMeter - chr1:151406282 124.4 161212000 1296190.8
00:42:11.594 INFO ProgressMeter - chr1:153942285 124.5 161348000 1295540.2
00:42:21.734 INFO ProgressMeter - chr1:155139907 124.7 161483000 1294867.1
00:42:31.808 INFO ProgressMeter - chr1:156335724 124.9 161587000 1293958.9
00:42:41.835 INFO ProgressMeter - chr1:158845638 125.0 161717000 1293269.2
00:42:51.900 INFO ProgressMeter - chr1:160550563 125.2 161881000 1292846.4
00:43:01.914 INFO ProgressMeter - chr1:161519755 125.4 162031000 1292321.8
00:43:18.894 INFO ProgressMeter - chr1:161589584 125.7 162083000 1289825.2
00:43:28.913 INFO ProgressMeter - chr1:167633579 125.8 162335000 1290116.2
00:43:38.947 INFO ProgressMeter - chr1:171319076 126.0 162484000 1289586.6
00:43:49.022 INFO ProgressMeter - chr1:174644731 126.2 162641000 1289114.5
00:43:59.037 INFO ProgressMeter - chr1:178569195 126.3 162771000 1288440.3
00:44:09.070 INFO ProgressMeter - chr1:183545492 126.5 162970000 1288310.2
00:44:26.506 INFO ProgressMeter - chr1:183573231 126.8 163009000 1285665.0
00:44:36.551 INFO ProgressMeter - chr1:192129791 127.0 163234000 1285741.9
00:44:46.572 INFO ProgressMeter - chr1:198649205 127.1 163376000 1285169.7
00:44:56.600 INFO ProgressMeter - chr1:198733863 127.3 163530000 1284692.3
00:45:06.642 INFO ProgressMeter - chr1:202559250 127.5 163640000 1283868.2
00:45:16.683 INFO ProgressMeter - chr1:203798007 127.6 163784000 1283313.0
00:45:26.709 INFO ProgressMeter - chr1:206498502 127.8 163906000 1282589.6
00:45:41.942 INFO ProgressMeter - chr1:206558391 128.0 163909000 1280070.0
00:45:51.964 INFO ProgressMeter - chr1:207685432 128.2 164057000 1279556.7
00:46:02.002 INFO ProgressMeter - chr1:215616316 128.4 164229000 1279229.0
00:46:12.059 INFO ProgressMeter - chr1:224398892 128.5 164361000 1278587.9
00:46:22.120 INFO ProgressMeter - chr1:226728708 128.7 164487000 1277901.1
00:46:32.239 INFO ProgressMeter - chr1:230899891 128.9 164599000 1277097.9
00:46:42.261 INFO ProgressMeter - chr1:235124952 129.1 164723000 1276405.8
00:47:05.705 INFO ProgressMeter - chr1:235810474 129.4 164820000 1273302.3
00:47:15.729 INFO ProgressMeter - chr1:244854376 129.6 164986000 1272941.7
00:47:25.749 INFO ProgressMeter - chr1:248823243 129.8 165130000 1272413.3
00:47:47.412 INFO ProgressMeter - chr2:218383 130.1 165136000 1268929.3
00:47:57.421 INFO ProgressMeter - chr2:23863451 130.3 165502000 1270113.6
00:48:07.439 INFO ProgressMeter - chr2:28160419 130.5 165718000 1270143.7
00:48:17.503 INFO ProgressMeter - chr2:36560582 130.6 165904000 1269936.7
00:48:27.530 INFO ProgressMeter - chr2:40384762 130.8 166111000 1269896.7
00:48:37.550 INFO ProgressMeter - chr2:45909973 131.0 166284000 1269598.4
00:48:47.597 INFO ProgressMeter - chr2:55235456 131.1 166463000 1269342.2
00:48:57.649 INFO ProgressMeter - chr2:63219186 131.3 166608000 1268827.0
00:49:07.677 INFO ProgressMeter - chr2:65074565 131.5 166743000 1268240.8
00:49:27.148 INFO ProgressMeter - chr2:70150308 131.8 167013000 1267166.7
00:49:37.224 INFO ProgressMeter - chr2:74152008 132.0 167176000 1266789.4
00:49:47.301 INFO ProgressMeter - chr2:85386937 132.1 167339000 1266412.8
00:49:57.360 INFO ProgressMeter - chr2:87722330 132.3 167483000 1265896.5
00:50:07.481 INFO ProgressMeter - chr2:96278677 132.5 167592000 1265107.5
00:50:17.564 INFO ProgressMeter - chr2:97836252 132.6 167692000 1264258.5
00:50:27.611 INFO ProgressMeter - chr2:100007338 132.8 167852000 1263869.3
00:50:45.053 INFO ProgressMeter - chr2:101305504 133.1 167936000 1261739.9
00:50:55.110 INFO ProgressMeter - chr2:105893575 133.3 168088000 1261293.5
00:51:05.113 INFO ProgressMeter - chr2:112378568 133.4 168242000 1260871.7
00:51:15.142 INFO ProgressMeter - chr2:119979978 133.6 168400000 1260477.0
00:51:25.202 INFO ProgressMeter - chr2:127322146 133.8 168542000 1259958.5
00:51:35.244 INFO ProgressMeter - chr2:134362846 133.9 168668000 1259324.8
00:51:45.264 INFO ProgressMeter - chr2:143097785 134.1 168796000 1258711.0
00:52:01.540 INFO ProgressMeter - chr2:143289617 134.4 168874000 1256750.6
00:52:11.568 INFO ProgressMeter - chr2:148260095 134.5 169215000 1257723.8
00:52:21.575 INFO ProgressMeter - chr2:157868623 134.7 169366000 1257287.6
00:52:31.607 INFO ProgressMeter - chr2:161504055 134.9 169531000 1256952.3
00:52:41.627 INFO ProgressMeter - chr2:169841234 135.0 169657000 1256330.9
00:52:51.633 INFO ProgressMeter - chr2:174368828 135.2 169766000 1255587.5
00:53:10.269 INFO ProgressMeter - chr2:174617456 135.5 169835000 1253219.0
00:53:20.284 INFO ProgressMeter - chr2:179319251 135.7 169983000 1252768.0
00:53:30.318 INFO ProgressMeter - chr2:190272859 135.9 170153000 1252477.2
00:53:40.370 INFO ProgressMeter - chr2:197007815 136.0 170366000 1252500.5
00:53:50.394 INFO ProgressMeter - chr2:197420884 136.2 170551000 1252322.5
00:54:00.520 INFO ProgressMeter - chr2:201273300 136.4 170717000 1251989.9
00:54:17.578 INFO ProgressMeter - chr2:201478189 136.6 170763000 1249721.6
00:54:27.606 INFO ProgressMeter - chr2:208308889 136.8 170919000 1249335.1
00:54:37.611 INFO ProgressMeter - chr2:218263757 137.0 171130000 1249354.7
00:54:47.642 INFO ProgressMeter - chr2:223817755 137.1 171229000 1248553.5
00:54:57.730 INFO ProgressMeter - chr2:229805949 137.3 171383000 1248146.2
00:55:07.864 INFO ProgressMeter - chr2:231711359 137.5 171552000 1247842.1
00:55:31.386 INFO ProgressMeter - chr2:234493755 137.9 171665000 1245113.5
00:55:41.402 INFO ProgressMeter - chr2:241080488 138.0 171817000 1244708.9
00:56:06.165 INFO ProgressMeter - chr3:2186530 138.5 171876000 1241424.6
00:56:16.194 INFO ProgressMeter - chr3:14131641 138.6 172244000 1242582.4
00:56:26.221 INFO ProgressMeter - chr3:15738525 138.8 172457000 1242620.9
00:56:36.221 INFO ProgressMeter - chr3:15738551 139.0 172794000 1243555.8
00:56:46.229 INFO ProgressMeter - chr3:15738573 139.1 173132000 1244494.3
00:56:56.235 INFO ProgressMeter - chr3:15738596 139.3 173473000 1245452.5
00:57:06.257 INFO ProgressMeter - chr3:15738617 139.5 173812000 1246391.7
00:57:18.949 INFO ProgressMeter - chr3:15738617 139.7 173835000 1244668.6
00:57:28.953 INFO ProgressMeter - chr3:15738619 139.8 174171000 1245587.4
00:57:38.976 INFO ProgressMeter - chr3:15738621 140.0 174506000 1246494.0
00:57:49.027 INFO ProgressMeter - chr3:17380136 140.2 174778000 1246944.8
00:58:07.063 INFO ProgressMeter - chr3:18424744 140.5 174831000 1244653.6
00:58:17.084 INFO ProgressMeter - chr3:28265197 140.6 174972000 1244178.1
00:58:27.161 INFO ProgressMeter - chr3:36838918 140.8 175175000 1244135.8
00:58:37.193 INFO ProgressMeter - chr3:39413554 141.0 175294000 1243504.3
00:58:47.203 INFO ProgressMeter - chr3:44819084 141.1 175452000 1243153.8
00:58:57.228 INFO ProgressMeter - chr3:47423553 141.3 175565000 1242483.6
00:59:07.307 INFO ProgressMeter - chr3:49268048 141.5 175650000 1241609.1
00:59:32.741 INFO ProgressMeter - chr3:50121896 141.9 175745000 1238569.3
00:59:42.898 INFO ProgressMeter - chr3:52543905 142.1 175864000 1237931.1
00:59:52.943 INFO ProgressMeter - chr3:57571688 142.2 175986000 1237331.7
01:00:02.949 INFO ProgressMeter - chr3:67640797 142.4 176147000 1237013.3
01:00:13.001 INFO ProgressMeter - chr3:71464797 142.6 176295000 1236597.7
01:00:23.114 INFO ProgressMeter - chr3:97918241 142.7 176457000 1236272.5
01:00:33.145 INFO ProgressMeter - chr3:105685223 142.9 176558000 1235532.9
01:00:54.735 INFO ProgressMeter - chr3:111603718 143.3 176684000 1233309.1
01:01:04.768 INFO ProgressMeter - chr3:114557013 143.4 176822000 1232833.4
01:01:14.790 INFO ProgressMeter - chr3:122440483 143.6 177020000 1232778.2
01:01:24.813 INFO ProgressMeter - chr3:125259769 143.8 177142000 1232194.3
01:01:34.883 INFO ProgressMeter - chr3:129233550 143.9 177267000 1231626.0
01:01:45.042 INFO ProgressMeter - chr3:133626416 144.1 177379000 1230956.0
01:01:55.062 INFO ProgressMeter - chr3:134971708 144.3 177528000 1230563.9
01:02:19.038 INFO ProgressMeter - chr3:141418970 144.7 177630000 1227869.9
01:02:29.090 INFO ProgressMeter - chr3:149154304 144.8 177778000 1227471.4
01:02:39.124 INFO ProgressMeter - chr3:152304124 145.0 177938000 1227159.2
01:02:49.168 INFO ProgressMeter - chr3:153162795 145.2 178094000 1226818.7
01:02:59.188 INFO ProgressMeter - chr3:161429278 145.3 178239000 1226406.7
01:03:09.249 INFO ProgressMeter - chr3:172094046 145.5 178354000 1225783.7
01:03:19.359 INFO ProgressMeter - chr3:182885955 145.7 178537000 1225622.1
01:03:39.929 INFO ProgressMeter - chr3:183859202 146.0 178582000 1223052.5
01:03:49.929 INFO ProgressMeter - chr3:187030622 146.2 178707000 1222513.2
01:03:59.943 INFO ProgressMeter - chr3:195326238 146.3 178922000 1222588.1
01:04:09.956 INFO ProgressMeter - chr3:197697227 146.5 179061000 1222144.4
01:04:39.253 INFO ProgressMeter - chr4:41192 147.0 179134000 1218581.4
01:04:49.257 INFO ProgressMeter - chr4:10442268 147.2 179456000 1219388.8
01:04:59.271 INFO ProgressMeter - chr4:37989551 147.3 179789000 1220267.6
01:05:09.312 INFO ProgressMeter - chr4:42486284 147.5 179989000 1220239.0
01:05:19.318 INFO ProgressMeter - chr4:53985332 147.7 180143000 1219903.9
01:05:29.362 INFO ProgressMeter - chr4:73113031 147.8 180292000 1219530.4
01:05:39.387 INFO ProgressMeter - chr4:79913799 148.0 180469000 1219349.6
01:05:49.464 INFO ProgressMeter - chr4:85476649 148.2 180616000 1218959.6
01:05:59.510 INFO ProgressMeter - chr4:89093753 148.3 180767000 1218601.6
01:06:09.530 INFO ProgressMeter - chr4:101138239 148.5 180952000 1218477.0
01:06:22.893 INFO ProgressMeter - chr4:101300623 148.7 180984000 1216867.5
01:06:32.912 INFO ProgressMeter - chr4:105147926 148.9 181125000 1216449.8
01:06:42.926 INFO ProgressMeter - chr4:112320108 149.1 181314000 1216355.7
01:06:52.951 INFO ProgressMeter - chr4:120768217 149.2 181452000 1215918.7
01:07:02.968 INFO ProgressMeter - chr4:129064063 149.4 181560000 1215282.7
01:07:12.978 INFO ProgressMeter - chr4:143400061 149.6 181764000 1215291.1
01:07:22.992 INFO ProgressMeter - chr4:150828274 149.7 181877000 1214691.3
01:07:39.709 INFO ProgressMeter - chr4:152626722 150.0 181937000 1212835.0
01:07:49.729 INFO ProgressMeter - chr4:159294383 150.2 182103000 1212591.7
01:07:59.782 INFO ProgressMeter - chr4:173244665 150.3 182248000 1212204.9
01:08:09.781 INFO ProgressMeter - chr4:184769531 150.5 182371000 1211679.8
01:08:36.305 INFO ProgressMeter - chr5:198737 151.0 182446000 1208628.3
01:08:46.347 INFO ProgressMeter - chr5:35876384 151.1 182800000 1209632.2
01:08:56.349 INFO ProgressMeter - chr5:39202597 151.3 183029000 1209813.1
01:09:06.368 INFO ProgressMeter - chr5:50708920 151.5 183209000 1209667.6
01:09:16.387 INFO ProgressMeter - chr5:56927880 151.6 183421000 1209733.6
01:09:26.498 INFO ProgressMeter - chr5:67158825 151.8 183599000 1209563.2
01:09:36.525 INFO ProgressMeter - chr5:70156927 152.0 183791000 1209496.5
01:09:49.564 INFO ProgressMeter - chr5:70816500 152.2 183958000 1208866.7
01:09:59.630 INFO ProgressMeter - chr5:75699220 152.3 184199000 1209117.4
01:10:17.920 INFO ProgressMeter - chr5:80173070 152.6 184352000 1207705.1
01:10:27.968 INFO ProgressMeter - chr5:87334159 152.8 184517000 1207461.4
01:10:37.986 INFO ProgressMeter - chr5:94582388 153.0 184704000 1207365.9
01:10:48.042 INFO ProgressMeter - chr5:97087522 153.1 184835000 1206900.0
01:10:58.050 INFO ProgressMeter - chr5:108016599 153.3 184972000 1206480.5
01:11:08.069 INFO ProgressMeter - chr5:113272961 153.5 185141000 1206269.0
01:11:18.113 INFO ProgressMeter - chr5:122827455 153.6 185287000 1205905.0
01:11:32.694 INFO ProgressMeter - chr5:126461015 153.9 185309000 1204143.7
01:11:42.755 INFO ProgressMeter - chr5:132422983 154.1 185451000 1203754.8
01:11:52.764 INFO ProgressMeter - chr5:134727209 154.2 185597000 1203399.4
01:12:02.766 INFO ProgressMeter - chr5:139367591 154.4 185729000 1202955.0
01:12:12.858 INFO ProgressMeter - chr5:141931276 154.6 185841000 1202370.6
01:12:22.936 INFO ProgressMeter - chr5:146251579 154.7 186099000 1202732.9
01:12:32.958 INFO ProgressMeter - chr5:150401943 154.9 186213000 1202171.8
01:12:47.881 INFO ProgressMeter - chr5:150405164 155.1 186232000 1200367.0
01:12:57.991 INFO ProgressMeter - chr5:154814485 155.3 186394000 1200107.8
01:13:07.995 INFO ProgressMeter - chr5:160099447 155.5 186564000 1199914.2
01:13:18.008 INFO ProgressMeter - chr5:169932916 155.6 186711000 1199572.1
01:13:28.015 INFO ProgressMeter - chr5:172090499 155.8 186842000 1199128.8
01:13:38.054 INFO ProgressMeter - chr5:176946965 156.0 187017000 1198964.5
01:13:48.078 INFO ProgressMeter - chr5:178210762 156.1 187115000 1198309.3
01:14:05.040 INFO ProgressMeter - chr5:179577107 156.4 187133000 1196258.8
01:14:31.983 INFO ProgressMeter - chr6:140071 156.9 187296000 1193873.7
01:14:41.992 INFO ProgressMeter - chr6:16578165 157.0 187789000 1195744.7
01:14:51.992 INFO ProgressMeter - chr6:24909584 157.2 188132000 1196658.8
01:15:02.084 INFO ProgressMeter - chr6:29725519 157.4 188407000 1197127.3
01:15:12.099 INFO ProgressMeter - chr6:30590870 157.5 188639000 1197331.5
01:15:22.119 INFO ProgressMeter - chr6:31271259 157.7 188767000 1196875.3
01:15:32.182 INFO ProgressMeter - chr6:31465280 157.9 188906000 1196484.3
01:15:42.283 INFO ProgressMeter - chr6:31971342 158.1 189008000 1195855.2
01:16:00.897 INFO ProgressMeter - chr6:32927943 158.4 189107000 1194137.6
01:16:10.954 INFO ProgressMeter - chr6:35087086 158.5 189254000 1193802.3
01:16:20.967 INFO ProgressMeter - chr6:36598968 158.7 189402000 1193479.5
01:16:30.984 INFO ProgressMeter - chr6:41190341 158.9 189599000 1193465.5
01:16:41.027 INFO ProgressMeter - chr6:42691465 159.0 189731000 1193039.4
01:16:51.152 INFO ProgressMeter - chr6:44296230 159.2 189809000 1192264.6
01:17:14.492 INFO ProgressMeter - chr6:52995646 159.6 190028000 1190730.7
01:17:24.504 INFO ProgressMeter - chr6:52995743 159.8 190348000 1191490.0
01:17:34.517 INFO ProgressMeter - chr6:52995832 159.9 190662000 1192210.1
01:17:44.834 INFO ProgressMeter - chr6:56842838 160.1 190906000 1192453.7
01:18:08.507 INFO ProgressMeter - chr6:70679173 160.5 191013000 1190188.9
01:18:18.519 INFO ProgressMeter - chr6:75678178 160.7 191229000 1190297.3
01:18:28.613 INFO ProgressMeter - chr6:89160231 160.8 191430000 1190301.9
01:18:38.614 INFO ProgressMeter - chr6:99410845 161.0 191570000 1189939.1
01:18:48.614 INFO ProgressMeter - chr6:108647116 161.2 191729000 1189695.1
01:18:58.634 INFO ProgressMeter - chr6:111714523 161.3 191870000 1189337.6
01:19:16.745 INFO ProgressMeter - chr6:116122322 161.6 191929000 1187481.4
01:19:26.776 INFO ProgressMeter - chr6:126002632 161.8 192072000 1187138.2
01:19:36.832 INFO ProgressMeter - chr6:132748067 162.0 192236000 1186922.3
01:19:46.983 INFO ProgressMeter - chr6:138918697 162.1 192380000 1186572.0
01:19:56.984 INFO ProgressMeter - chr6:144187871 162.3 192536000 1186314.5
01:20:07.086 INFO ProgressMeter - chr6:145944440 162.5 192660000 1185848.4
01:20:17.175 INFO ProgressMeter - chr6:152220960 162.6 192790000 1185421.8
01:20:38.989 INFO ProgressMeter - chr6:154809367 163.0 192865000 1183237.7
01:20:49.029 INFO ProgressMeter - chr6:158815980 163.2 193022000 1182986.4
01:20:59.053 INFO ProgressMeter - chr6:160065402 163.3 193187000 1182786.6
01:21:09.126 INFO ProgressMeter - chr6:167925031 163.5 193367000 1182673.0
01:21:37.895 INFO ProgressMeter - chr7:10435 164.0 193418000 1179525.8
01:21:47.931 INFO ProgressMeter - chr7:7274037 164.1 193796000 1180626.7
01:21:57.982 INFO ProgressMeter - chr7:23602990 164.3 194006000 1180701.2
01:22:07.984 INFO ProgressMeter - chr7:28447957 164.5 194166000 1180477.3
01:22:17.998 INFO ProgressMeter - chr7:32530923 164.6 194343000 1180355.6
01:22:28.014 INFO ProgressMeter - chr7:36657263 164.8 194507000 1180155.2
01:22:38.023 INFO ProgressMeter - chr7:37762104 165.0 194657000 1179871.1
01:22:48.133 INFO ProgressMeter - chr7:44576050 165.2 194834000 1179739.0
01:22:58.134 INFO ProgressMeter - chr7:50690323 165.3 195025000 1179704.9
01:23:08.146 INFO ProgressMeter - chr7:70777755 165.5 195177000 1179433.9
01:23:31.642 INFO ProgressMeter - chr7:74779364 165.9 195296000 1177366.8
01:23:41.671 INFO ProgressMeter - chr7:80638740 166.0 195511000 1177476.5
01:23:51.751 INFO ProgressMeter - chr7:92195754 166.2 195629000 1176996.3
01:24:01.765 INFO ProgressMeter - chr7:98965802 166.4 195758000 1176590.9
01:24:11.837 INFO ProgressMeter - chr7:100404079 166.5 195859000 1176011.5
01:24:21.850 INFO ProgressMeter - chr7:102582320 166.7 195951000 1175386.1
01:24:31.866 INFO ProgressMeter - chr7:105664136 166.9 196094000 1175067.2
01:24:48.897 INFO ProgressMeter - chr7:106272578 167.2 196213000 1173783.8
01:24:58.933 INFO ProgressMeter - chr7:111548388 167.3 196400000 1173728.0
01:25:09.005 INFO ProgressMeter - chr7:122138090 167.5 196545000 1173417.3
01:25:19.106 INFO ProgressMeter - chr7:129532858 167.7 196669000 1172978.7
01:25:29.139 INFO ProgressMeter - chr7:133655700 167.8 196877000 1173049.4
01:25:39.186 INFO ProgressMeter - chr7:138579558 168.0 197014000 1172695.6
01:26:01.918 INFO ProgressMeter - chr7:140117996 168.4 197164000 1170947.8
01:26:12.031 INFO ProgressMeter - chr7:142353102 168.5 197330000 1170761.7
01:26:22.096 INFO ProgressMeter - chr7:149154070 168.7 197486000 1170522.3
01:26:32.383 INFO ProgressMeter - chr7:151071129 168.9 197618000 1170115.6
01:26:42.400 INFO ProgressMeter - chr7:155680638 169.1 197738000 1169669.9
01:27:14.347 INFO ProgressMeter - chr8:64898 169.6 197828000 1166528.2
01:27:24.415 INFO ProgressMeter - chr8:22624510 169.8 198238000 1167790.4
01:27:34.415 INFO ProgressMeter - chr8:23571851 169.9 198479000 1168063.2
01:27:44.479 INFO ProgressMeter - chr8:27517719 170.1 198704000 1168234.2
01:27:54.812 INFO ProgressMeter - chr8:38242268 170.3 198842000 1167863.1
01:28:04.880 INFO ProgressMeter - chr8:47898764 170.4 199040000 1167875.0
01:28:14.919 INFO ProgressMeter - chr8:58578157 170.6 199258000 1168007.4
01:28:24.980 INFO ProgressMeter - chr8:65934242 170.8 199402000 1167703.8
01:28:34.993 INFO ProgressMeter - chr8:73804557 170.9 199565000 1167517.3
01:28:53.099 INFO ProgressMeter - chr8:81283422 171.2 199665000 1166043.8
01:29:03.109 INFO ProgressMeter - chr8:96259213 171.4 199801000 1165702.3
01:29:13.112 INFO ProgressMeter - chr8:99211056 171.6 199945000 1165409.0
01:29:23.117 INFO ProgressMeter - chr8:102284241 171.7 200141000 1165418.6
01:29:33.126 INFO ProgressMeter - chr8:118366239 171.9 200293000 1165171.8
01:29:43.154 INFO ProgressMeter - chr8:124625081 172.1 200430000 1164836.3
01:29:53.162 INFO ProgressMeter - chr8:129954161 172.2 200573000 1164538.5
01:30:07.420 INFO ProgressMeter - chr8:130124048 172.5 200602000 1163102.2
01:30:17.458 INFO ProgressMeter - chr8:133470609 172.6 200796000 1163098.7
01:30:27.510 INFO ProgressMeter - chr8:141192908 172.8 200933000 1162763.9
01:30:37.521 INFO ProgressMeter - chr8:144106432 173.0 201041000 1162266.6
01:31:03.871 INFO ProgressMeter - chr9:13489 173.4 201083000 1159565.4
01:31:13.882 INFO ProgressMeter - chr9:9442098 173.6 201674000 1161855.6
01:31:23.900 INFO ProgressMeter - chr9:9442121 173.7 202088000 1163122.0
01:31:33.910 INFO ProgressMeter - chr9:9442141 173.9 202501000 1164380.9
01:31:43.919 INFO ProgressMeter - chr9:9442162 174.1 202896000 1165534.1
01:32:01.429 INFO ProgressMeter - chr9:9442163 174.4 203053000 1164483.8
01:32:11.454 INFO ProgressMeter - chr9:15162306 174.5 203943000 1168468.2
01:32:31.955 INFO ProgressMeter - chr9:21813406 174.9 204042000 1166751.3
01:32:41.996 INFO ProgressMeter - chr9:34107523 175.0 204276000 1166972.7
01:32:52.025 INFO ProgressMeter - chr9:35851450 175.2 204417000 1166664.1
01:33:02.097 INFO ProgressMeter - chr9:40992540 175.4 204568000 1166408.5
01:33:12.098 INFO ProgressMeter - chr9:68249317 175.5 204738000 1166269.3
01:33:22.138 INFO ProgressMeter - chr9:75149951 175.7 204865000 1165881.5
01:33:43.839 INFO ProgressMeter - chr9:78024527 176.1 204968000 1164071.6
01:33:53.881 INFO ProgressMeter - chr9:86302155 176.2 205135000 1163913.7
01:34:04.021 INFO ProgressMeter - chr9:92313075 176.4 205327000 1163887.1
01:34:14.031 INFO ProgressMeter - chr9:95882271 176.6 205460000 1163540.6
01:34:24.036 INFO ProgressMeter - chr9:100098932 176.7 205580000 1163121.8
01:34:34.093 INFO ProgressMeter - chr9:111666929 176.9 205686000 1162619.0
01:34:44.122 INFO ProgressMeter - chr9:113386608 177.1 205821000 1162284.0
01:35:04.542 INFO ProgressMeter - chr9:114915019 177.4 205898000 1160488.5
01:35:14.558 INFO ProgressMeter - chr9:121821252 177.6 206052000 1160264.8
01:35:24.594 INFO ProgressMeter - chr9:125767791 177.8 206220000 1160118.1
01:35:34.811 INFO ProgressMeter - chr9:128494629 177.9 206324000 1159592.3
01:35:44.825 INFO ProgressMeter - chr9:130581219 178.1 206426000 1159078.3
01:35:54.844 INFO ProgressMeter - chr9:133020324 178.3 206587000 1158895.8
01:36:04.957 INFO ProgressMeter - chr9:135901860 178.4 206710000 1158490.4
01:36:15.062 INFO ProgressMeter - chr9:137389412 178.6 206777000 1157773.1
01:36:32.669 INFO ProgressMeter - chr9:137718475 178.9 206789000 1155941.0
01:36:50.862 INFO ProgressMeter - chr10:140030 179.2 206857000 1154364.5
01:37:00.876 INFO ProgressMeter - chr10:12101175 179.4 207314000 1155838.3
01:37:10.898 INFO ProgressMeter - chr10:17686896 179.5 207514000 1155876.9
01:37:20.949 INFO ProgressMeter - chr10:24705447 179.7 207719000 1155940.2
01:37:30.981 INFO ProgressMeter - chr10:30450500 179.9 207905000 1155899.7
01:37:41.035 INFO ProgressMeter - chr10:35440298 180.0 208060000 1155684.8
01:37:51.040 INFO ProgressMeter - chr10:45461353 180.2 208237000 1155597.6
01:38:01.051 INFO ProgressMeter - chr10:46595060 180.4 208364000 1155232.8
01:38:11.074 INFO ProgressMeter - chr10:58337563 180.5 208518000 1155016.8
01:38:21.125 INFO ProgressMeter - chr10:63207324 180.7 208651000 1154682.2
01:38:39.655 INFO ProgressMeter - chr10:68968101 181.0 208731000 1153154.0
01:38:49.689 INFO ProgressMeter - chr10:71769340 181.2 208868000 1152845.7
01:38:59.695 INFO ProgressMeter - chr10:73821720 181.3 209036000 1152712.1
01:39:09.814 INFO ProgressMeter - chr10:80138252 181.5 209209000 1152594.1
01:39:19.858 INFO ProgressMeter - chr10:87887650 181.7 209356000 1152341.2
01:39:29.929 INFO ProgressMeter - chr10:91853054 181.8 209509000 1152119.0
01:39:39.929 INFO ProgressMeter - chr10:95890857 182.0 209614000 1151640.9
01:39:55.297 INFO ProgressMeter - chr10:96616430 182.3 209648000 1150209.0
01:40:05.321 INFO ProgressMeter - chr10:100536629 182.4 209786000 1149912.1
01:40:15.324 INFO ProgressMeter - chr10:103149922 182.6 209926000 1149629.0
01:40:25.367 INFO ProgressMeter - chr10:111015989 182.8 210074000 1149385.9
01:40:35.437 INFO ProgressMeter - chr10:119515592 182.9 210250000 1149293.4
01:40:45.463 INFO ProgressMeter - chr10:124699624 183.1 210436000 1149260.4
01:40:55.591 INFO ProgressMeter - chr10:132346656 183.3 210567000 1148916.7
01:41:12.687 INFO ProgressMeter - chr10:132764307 183.6 210583000 1147220.4
01:41:28.929 INFO ProgressMeter - chr11:111804 183.8 210609000 1145672.6
01:41:38.972 INFO ProgressMeter - chr11:5225464 184.0 210960000 1146537.9
01:41:48.995 INFO ProgressMeter - chr11:5225471 184.2 211152000 1146540.5
01:41:59.017 INFO ProgressMeter - chr11:5225492 184.3 211344000 1146543.2
01:42:09.045 INFO ProgressMeter - chr11:5225493 184.5 211536000 1146545.2
01:42:19.085 INFO ProgressMeter - chr11:5225495 184.7 211728000 1146546.0
01:42:29.134 INFO ProgressMeter - chr11:5225527 184.8 211920000 1146545.8
01:42:39.159 INFO ProgressMeter - chr11:5225535 185.0 212106000 1146515.7
01:42:49.167 INFO ProgressMeter - chr11:5225538 185.2 212275000 1146395.6
01:42:59.188 INFO ProgressMeter - chr11:5225544 185.3 212457000 1146344.5
01:43:12.482 INFO ProgressMeter - chr11:5225544 185.6 212470000 1145045.8
01:43:22.508 INFO ProgressMeter - chr11:5225554 185.7 212653000 1145000.9
01:43:32.548 INFO ProgressMeter - chr11:5225566 185.9 212836000 1144954.7
01:43:42.597 INFO ProgressMeter - chr11:5225579 186.1 213016000 1144891.4
01:43:52.624 INFO ProgressMeter - chr11:5225579 186.2 213198000 1144841.3
01:44:02.656 INFO ProgressMeter - chr11:5225580 186.4 213380000 1144790.8
01:44:21.591 INFO ProgressMeter - chr11:5225580 186.7 213463000 1143300.4
01:44:31.632 INFO ProgressMeter - chr11:5225582 186.9 213645000 1143250.4
01:44:41.683 INFO ProgressMeter - chr11:5225583 187.0 213827000 1143199.6
01:44:51.689 INFO ProgressMeter - chr11:5225585 187.2 214003000 1143121.3
01:45:01.720 INFO ProgressMeter - chr11:5225592 187.4 214173000 1143008.7
01:45:11.721 INFO ProgressMeter - chr11:5225597 187.5 214350000 1142936.6
01:45:27.052 INFO ProgressMeter - chr11:5225600 187.8 214395000 1141621.1
01:45:37.065 INFO ProgressMeter - chr11:5225622 188.0 214946000 1143538.9
01:46:02.503 INFO ProgressMeter - chr11:5225645 188.4 215394000 1143343.6
01:46:12.525 INFO ProgressMeter - chr11:5225657 188.6 215845000 1144722.5
01:46:38.040 INFO ProgressMeter - chr11:5225659 189.0 216067000 1143321.3
01:46:48.059 INFO ProgressMeter - chr11:5225665 189.1 216460000 1144389.7
01:47:09.676 INFO ProgressMeter - chr11:5225668 189.5 216664000 1143290.6
01:47:19.702 INFO ProgressMeter - chr11:5225671 189.7 216962000 1143854.4
01:47:42.909 INFO ProgressMeter - chr11:5225672 190.1 217211000 1142836.7
01:47:52.920 INFO ProgressMeter - chr11:5225689 190.2 217612000 1143942.4
01:48:17.532 INFO ProgressMeter - chr11:5225695 190.6 217852000 1142739.8
01:48:27.534 INFO ProgressMeter - chr11:5225711 190.8 218213000 1143633.4
01:48:51.552 INFO ProgressMeter - chr11:5225724 191.2 218413000 1142285.2
01:49:01.565 INFO ProgressMeter - chr11:5226587 191.4 218783000 1143222.5
01:49:28.155 INFO ProgressMeter - chr11:5226598 191.8 219223000 1142875.1
01:49:39.925 INFO ProgressMeter - chr11:5226605 192.0 219656000 1143962.5
01:49:49.932 INFO ProgressMeter - chr11:5226625 192.2 220113000 1145347.7
01:50:06.593 INFO ProgressMeter - chr11:5226628 192.5 220161000 1143944.6
01:50:16.607 INFO ProgressMeter - chr11:5226647 192.6 220600000 1145232.5
01:50:43.058 INFO ProgressMeter - chr11:5226655 193.1 220962000 1144492.4
01:50:53.069 INFO ProgressMeter - chr11:5226671 193.2 221295000 1145227.6
01:51:03.075 INFO ProgressMeter - chr11:5226688 193.4 221767000 1146680.5
01:51:22.815 INFO ProgressMeter - chr11:5226693 193.7 221826000 1145037.7
01:51:32.827 INFO ProgressMeter - chr11:5226713 193.9 222296000 1146476.3
01:51:44.879 INFO ProgressMeter - chr11:5226731 194.1 222653000 1147129.1
01:52:01.694 INFO ProgressMeter - chr11:5226731 194.4 222678000 1145603.8
01:52:11.711 INFO ProgressMeter - chr11:5226748 194.5 223014000 1146347.8
01:52:37.298 INFO ProgressMeter - chr11:5226770 195.0 223246000 1145030.4
01:52:47.303 INFO ProgressMeter - chr11:5226930 195.1 223484000 1145271.7
01:52:57.307 INFO ProgressMeter - chr11:5226946 195.3 223929000 1146572.3
01:53:18.446 INFO ProgressMeter - chr11:5226957 195.7 224012000 1144931.9
01:53:28.458 INFO ProgressMeter - chr11:5226978 195.8 224422000 1146050.0
01:53:38.469 INFO ProgressMeter - chr11:5234126 196.0 224858000 1147299.0
01:53:59.856 INFO ProgressMeter - chr11:6610911 196.3 224960000 1145735.6
01:54:09.876 INFO ProgressMeter - chr11:12116815 196.5 225176000 1145861.1
01:54:19.917 INFO ProgressMeter - chr11:14887103 196.7 225338000 1145709.8
01:54:29.952 INFO ProgressMeter - chr11:31698525 196.8 225456000 1145335.8
01:54:39.979 INFO ProgressMeter - chr11:35803064 197.0 225618000 1145186.6
01:54:50.107 INFO ProgressMeter - chr11:45809796 197.2 225711000 1144677.9
01:55:00.127 INFO ProgressMeter - chr11:47551647 197.3 225857000 1144449.0
01:55:16.618 INFO ProgressMeter - chr11:47991203 197.6 225877000 1142958.6
01:55:26.642 INFO ProgressMeter - chr11:59803620 197.8 226041000 1142822.3
01:55:36.673 INFO ProgressMeter - chr11:61980122 198.0 226153000 1142423.0
01:55:46.765 INFO ProgressMeter - chr11:62709711 198.1 226304000 1142215.2
01:55:56.772 INFO ProgressMeter - chr11:64738102 198.3 226386000 1141668.0
01:56:06.780 INFO ProgressMeter - chr11:65426304 198.5 226477000 1141167.0
01:56:16.823 INFO ProgressMeter - chr11:65502792 198.6 226701000 1141333.1
01:56:35.214 INFO ProgressMeter - chr11:65503618 198.9 226792000 1140032.0
01:56:45.242 INFO ProgressMeter - chr11:65505482 199.1 227007000 1140154.9
01:56:55.252 INFO ProgressMeter - chr11:65883328 199.3 227182000 1140078.5
01:57:05.273 INFO ProgressMeter - chr11:67398599 199.4 227306000 1139745.6
01:57:15.288 INFO ProgressMeter - chr11:69097574 199.6 227404000 1139283.4
01:57:25.323 INFO ProgressMeter - chr11:72828736 199.8 227506000 1138840.1
01:57:35.411 INFO ProgressMeter - chr11:74877701 199.9 227643000 1138567.7
01:57:55.892 INFO ProgressMeter - chr11:76052143 200.3 227713000 1136976.6
01:58:05.906 INFO ProgressMeter - chr11:83258173 200.4 227875000 1136838.1
01:58:15.983 INFO ProgressMeter - chr11:93179309 200.6 228030000 1136659.1
01:58:26.046 INFO ProgressMeter - chr11:102330082 200.8 228217000 1136640.9
01:58:36.046 INFO ProgressMeter - chr11:108226245 200.9 228337000 1136295.4
01:58:46.107 INFO ProgressMeter - chr11:114449879 201.1 228459000 1135954.6
01:58:56.192 INFO ProgressMeter - chr11:118382315 201.3 228611000 1135761.1
01:59:15.601 INFO ProgressMeter - chr11:118751840 201.6 228647000 1134117.4
01:59:25.608 INFO ProgressMeter - chr11:121553347 201.8 228819000 1134032.4
01:59:35.634 INFO ProgressMeter - chr11:124626573 201.9 229003000 1134005.1
01:59:45.642 INFO ProgressMeter - chr11:128797712 202.1 229216000 1134123.1
02:00:21.552 INFO ProgressMeter - chr12:14774 202.7 229302000 1131198.8
02:00:31.564 INFO ProgressMeter - chr12:8945571 202.9 229678000 1132121.8
02:00:41.571 INFO ProgressMeter - chr12:10123117 203.0 229908000 1132324.6
02:00:51.625 INFO ProgressMeter - chr12:14438145 203.2 230149000 1132576.9
02:01:01.680 INFO ProgressMeter - chr12:25079712 203.4 230316000 1132464.7
02:01:11.774 INFO ProgressMeter - chr12:30680971 203.5 230466000 1132265.7
02:01:21.808 INFO ProgressMeter - chr12:40284027 203.7 230648000 1132229.6
02:01:31.862 INFO ProgressMeter - chr12:45403229 203.9 230789000 1131990.6
02:01:41.959 INFO ProgressMeter - chr12:48695761 204.0 230966000 1131924.5
02:01:52.014 INFO ProgressMeter - chr12:50704729 204.2 231086000 1131583.2
02:02:09.341 INFO ProgressMeter - chr12:51296590 204.5 231135000 1130224.9
02:02:19.392 INFO ProgressMeter - chr12:54298082 204.7 231276000 1129988.7
02:02:29.448 INFO ProgressMeter - chr12:56346591 204.8 231401000 1129674.4
02:02:39.500 INFO ProgressMeter - chr12:57734460 205.0 231501000 1129239.0
02:02:49.537 INFO ProgressMeter - chr12:65188175 205.2 231704000 1129307.7
02:02:59.542 INFO ProgressMeter - chr12:68657149 205.3 231839000 1129048.1
02:03:21.556 INFO ProgressMeter - chr12:75507655 205.7 232011000 1127870.5
02:03:31.711 INFO ProgressMeter - chr12:88144083 205.9 232145000 1127594.2
02:03:41.748 INFO ProgressMeter - chr12:94634580 206.0 232367000 1127756.1
02:03:51.851 INFO ProgressMeter - chr12:101406757 206.2 232485000 1127407.4
02:04:01.860 INFO ProgressMeter - chr12:104624494 206.4 232624000 1127169.7
02:04:11.860 INFO ProgressMeter - chr12:108565359 206.5 232788000 1127054.1
02:04:21.884 INFO ProgressMeter - chr12:110549814 206.7 232908000 1126723.9
02:04:38.740 INFO ProgressMeter - chr12:111486769 207.0 232942000 1125358.8
02:04:48.831 INFO ProgressMeter - chr12:113280237 207.2 233056000 1124995.5
02:04:58.872 INFO ProgressMeter - chr12:120575941 207.3 233286000 1125196.8
02:05:09.056 INFO ProgressMeter - chr12:122981242 207.5 233395000 1124801.7
02:05:19.057 INFO ProgressMeter - chr12:124912287 207.7 233506000 1124433.4
02:05:29.177 INFO ProgressMeter - chr12:132657225 207.8 233687000 1124391.7
02:05:59.228 INFO ProgressMeter - chr13:18262479 208.3 233718000 1121837.4
02:06:09.264 INFO ProgressMeter - chr13:32528310 208.5 234076000 1122654.5
02:06:19.335 INFO ProgressMeter - chr13:42924372 208.7 234299000 1122820.1
02:06:29.356 INFO ProgressMeter - chr13:46153151 208.8 234441000 1122602.1
02:06:39.417 INFO ProgressMeter - chr13:50048479 209.0 234658000 1122739.7
02:06:49.461 INFO ProgressMeter - chr13:72844976 209.2 234809000 1122563.0
02:06:59.462 INFO ProgressMeter - chr13:77700862 209.3 234986000 1122514.7
02:07:09.480 INFO ProgressMeter - chr13:99528969 209.5 235150000 1122402.9
02:07:19.523 INFO ProgressMeter - chr13:111267742 209.7 235288000 1122165.1
02:07:29.588 INFO ProgressMeter - chr13:114120119 209.8 235398000 1121792.2
02:07:52.335 INFO ProgressMeter - chr14:17151098 210.2 235409000 1119821.5
02:08:02.351 INFO ProgressMeter - chr14:24441153 210.4 235839000 1120976.8
02:08:12.357 INFO ProgressMeter - chr14:49365940 210.6 236028000 1120986.6
02:08:22.379 INFO ProgressMeter - chr14:49538793 210.7 236223000 1121023.4
02:08:32.422 INFO ProgressMeter - chr14:49572997 210.9 236419000 1121063.0
02:08:42.469 INFO ProgressMeter - chr14:49581951 211.1 236585000 1120960.1
02:08:52.481 INFO ProgressMeter - chr14:49586588 211.2 236792000 1121054.5
02:09:11.946 INFO ProgressMeter - chr14:49586599 211.5 237186000 1121197.8
02:09:21.961 INFO ProgressMeter - chr14:49586633 211.7 237742000 1122940.1
02:09:43.711 INFO ProgressMeter - chr14:49586651 212.1 238162000 1123001.0
02:09:53.721 INFO ProgressMeter - chr14:49586679 212.2 238743000 1124855.8
02:10:16.275 INFO ProgressMeter - chr14:49586682 212.6 239149000 1124776.6
02:10:26.289 INFO ProgressMeter - chr14:49586684 212.8 239736000 1126653.0
02:10:50.450 INFO ProgressMeter - chr14:49586685 213.2 240149000 1126462.1
02:11:00.465 INFO ProgressMeter - chr14:49586703 213.4 240722000 1128266.5
02:11:10.466 INFO ProgressMeter - chr14:49586714 213.5 241127000 1129282.6
02:11:28.198 INFO ProgressMeter - chr14:49586715 213.8 241149000 1127824.5
02:11:38.198 INFO ProgressMeter - chr14:49586766 214.0 241728000 1129651.9
02:12:03.464 INFO ProgressMeter - chr14:49853689 214.4 242085000 1129098.3
02:12:13.468 INFO ProgressMeter - chr14:49862561 214.6 242829000 1131688.4
02:12:33.292 INFO ProgressMeter - chr14:49862575 214.9 242986000 1130679.0
02:12:43.299 INFO ProgressMeter - chr14:49862641 215.1 243790000 1133540.5
02:13:03.785 INFO ProgressMeter - chr14:49862644 215.4 243981000 1132630.4
02:13:13.795 INFO ProgressMeter - chr14:49862670 215.6 244602000 1134634.5
02:13:35.834 INFO ProgressMeter - chr14:49862671 215.9 244965000 1134385.5
02:13:45.837 INFO ProgressMeter - chr14:49862677 216.1 245816000 1137448.2
02:14:06.690 INFO ProgressMeter - chr14:49862687 216.5 245965000 1136310.3
02:14:16.691 INFO ProgressMeter - chr14:49862717 216.6 246849000 1139516.7
02:14:37.120 INFO ProgressMeter - chr14:49862721 217.0 246960000 1138240.1
02:14:47.122 INFO ProgressMeter - chr14:49862766 217.1 247770000 1141096.6
02:15:07.635 INFO ProgressMeter - chr14:49862768 217.5 247960000 1140176.4
02:15:17.700 INFO ProgressMeter - chr14:54834072 217.6 248194000 1140372.8
02:15:27.706 INFO ProgressMeter - chr14:60287686 217.8 248372000 1140316.9
02:15:37.765 INFO ProgressMeter - chr14:64742388 218.0 248566000 1140329.8
02:15:47.798 INFO ProgressMeter - chr14:68885987 218.1 248712000 1140125.0
02:15:57.805 INFO ProgressMeter - chr14:71346317 218.3 248888000 1140060.2
02:16:14.681 INFO ProgressMeter - chr14:71361251 218.6 248893000 1138616.2
02:16:24.689 INFO ProgressMeter - chr14:74496377 218.8 249040000 1138419.9
02:16:34.744 INFO ProgressMeter - chr14:81074892 218.9 249160000 1138096.6
02:16:44.826 INFO ProgressMeter - chr14:90288856 219.1 249293000 1137830.8
02:16:54.874 INFO ProgressMeter - chr14:92608088 219.3 249459000 1137718.8
02:17:04.879 INFO ProgressMeter - chr14:95289356 219.4 249582000 1137414.8
02:17:14.941 INFO ProgressMeter - chr14:100120328 219.6 249750000 1137311.2
02:17:37.883 INFO ProgressMeter - chr14:101990993 220.0 249834000 1135716.3
02:17:47.904 INFO ProgressMeter - chr14:104791632 220.1 249967000 1135458.7
02:18:13.910 INFO ProgressMeter - chr15:20032833 220.6 250037000 1133544.9
02:18:23.932 INFO ProgressMeter - chr15:34926402 220.7 250315000 1133946.7
02:18:33.993 INFO ProgressMeter - chr15:42943494 220.9 250490000 1133878.0
02:18:44.008 INFO ProgressMeter - chr15:44715583 221.1 250657000 1133777.3
02:18:54.059 INFO ProgressMeter - chr15:50576385 221.2 250835000 1133723.4
02:19:04.091 INFO ProgressMeter - chr15:57007056 221.4 251020000 1133702.8
02:19:14.163 INFO ProgressMeter - chr15:60469596 221.6 251179000 1133561.5
02:19:24.224 INFO ProgressMeter - chr15:63777813 221.8 251357000 1133507.0
02:19:34.312 INFO ProgressMeter - chr15:66548443 221.9 251512000 1133346.7
02:19:44.313 INFO ProgressMeter - chr15:72208698 222.1 251682000 1133261.6
02:19:54.315 INFO ProgressMeter - chr15:75218275 222.3 251808000 1132978.5
02:20:10.101 INFO ProgressMeter - chr15:76881776 222.5 251853000 1131841.1
02:20:20.107 INFO ProgressMeter - chr15:81979803 222.7 252008000 1131689.5
02:20:30.108 INFO ProgressMeter - chr15:89877176 222.8 252225000 1131816.8
02:20:40.147 INFO ProgressMeter - chr15:91961295 223.0 252371000 1131622.3
02:20:50.175 INFO ProgressMeter - chr15:99311892 223.2 252607000 1131832.3
02:21:21.859 INFO ProgressMeter - chr16:11734 223.7 252705000 1129598.7
02:21:43.791 INFO ProgressMeter - chr16:172892 224.1 254684000 1136587.8
02:22:03.342 INFO ProgressMeter - chr16:172915 224.4 255657000 1139273.4
02:22:25.674 INFO ProgressMeter - chr16:172951 224.8 256450000 1140914.8
02:22:47.226 INFO ProgressMeter - chr16:172972 225.1 257138000 1142150.4
02:23:10.667 INFO ProgressMeter - chr16:172975 225.5 257676000 1142557.4
02:23:31.516 INFO ProgressMeter - chr16:173007 225.9 258435000 1144160.0
02:23:54.379 INFO ProgressMeter - chr16:173167 226.3 259393000 1146467.2
02:24:17.700 INFO ProgressMeter - chr16:173193 226.6 260331000 1148639.7
02:24:42.999 INFO ProgressMeter - chr16:173226 227.1 261163000 1150170.9
02:25:08.218 INFO ProgressMeter - chr16:173250 227.5 262160000 1152428.6
02:25:18.219 INFO ProgressMeter - chr16:173262 227.7 262941000 1155015.4
02:25:35.139 INFO ProgressMeter - chr16:173262 227.9 262946000 1153608.3
02:25:45.500 INFO ProgressMeter - chr16:173277 228.1 263478000 1155067.2
02:26:04.399 INFO ProgressMeter - chr16:173278 228.4 263573000 1153890.4
02:26:30.245 INFO ProgressMeter - chr16:173290 228.9 264238000 1154624.2
02:26:40.250 INFO ProgressMeter - chr16:173299 229.0 264693000 1155770.2
02:26:58.047 INFO ProgressMeter - chr16:173299 229.3 264778000 1154645.9
02:27:08.053 INFO ProgressMeter - chr16:173309 229.5 265260000 1155907.2
02:27:24.117 INFO ProgressMeter - chr16:173313 229.7 265332000 1154873.6
02:27:34.120 INFO ProgressMeter - chr16:173327 229.9 265940000 1156680.6
02:27:50.526 INFO ProgressMeter - chr16:173327 230.2 265969000 1155432.6
02:28:00.528 INFO ProgressMeter - chr16:173474 230.4 266605000 1157357.4
02:28:19.262 INFO ProgressMeter - chr16:173477 230.7 266772000 1156514.8
02:28:29.266 INFO ProgressMeter - chr16:173498 230.8 267363000 1158239.7
02:28:45.728 INFO ProgressMeter - chr16:173505 231.1 267609000 1157929.1
02:28:55.735 INFO ProgressMeter - chr16:173513 231.3 268260000 1159908.9
02:29:14.799 INFO ProgressMeter - chr16:173516 231.6 268499000 1159349.6
02:29:26.306 INFO ProgressMeter - chr16:173530 231.8 269249000 1161626.0
02:29:45.410 INFO ProgressMeter - chr16:173534 232.1 269438000 1160846.8
02:29:58.003 INFO ProgressMeter - chr16:173549 232.3 270161000 1162910.2
02:30:15.836 INFO ProgressMeter - chr16:173552 232.6 270338000 1162185.2
02:30:28.059 INFO ProgressMeter - chr16:173584 232.8 270929000 1163706.8
02:30:48.040 INFO ProgressMeter - chr16:173585 233.1 271138000 1162941.0
02:30:59.610 INFO ProgressMeter - chr16:173588 233.3 271765000 1164667.0
02:31:19.404 INFO ProgressMeter - chr16:173589 233.7 271879000 1163510.6
02:31:30.206 INFO ProgressMeter - chr16:173601 233.9 272361000 1164676.1
02:31:53.758 INFO ProgressMeter - chr16:176694 234.2 272767000 1164457.5
02:32:17.890 INFO ProgressMeter - chr16:176729 234.6 273752000 1166659.4
02:32:40.950 INFO ProgressMeter - chr16:176770 235.0 274664000 1168632.0
02:33:06.097 INFO ProgressMeter - chr16:176778 235.4 275600000 1170527.1
02:33:16.105 INFO ProgressMeter - chr16:176791 235.6 276410000 1173136.2
02:33:35.168 INFO ProgressMeter - chr16:176793 235.9 276482000 1171861.6
02:33:45.169 INFO ProgressMeter - chr16:176811 236.1 276757000 1172199.1
02:34:07.481 INFO ProgressMeter - chr16:176958 236.5 277276000 1172550.5
02:34:18.800 INFO ProgressMeter - chr16:176992 236.7 278269000 1175811.7
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02:48:46.592 INFO SplitNCigarReads - Shutting down engine
[August 27, 2020 2:48:46 AM PDT] org.broadinstitute.hellbender.tools.walkers.rnaseq.SplitNCigarReads done. Elapsed time: 251.13 minutes.
Runtime.totalMemory()=76986974208
htsjdk.samtools.util.RuntimeIOException: Attempt to add record to closed writer.
at htsjdk.samtools.util.AbstractAsyncWriter.write(AbstractAsyncWriter.java:57)
at htsjdk.samtools.AsyncSAMFileWriter.addAlignment(AsyncSAMFileWriter.java:53)
at org.broadinstitute.hellbender.utils.read.SAMFileGATKReadWriter.addRead(SAMFileGATKReadWriter.java:21)
at org.broadinstitute.hellbender.tools.walkers.rnaseq.OverhangFixingManager.writeReads(OverhangFixingManager.java:358)
at org.broadinstitute.hellbender.tools.walkers.rnaseq.OverhangFixingManager.flush(OverhangFixingManager.java:338)
at org.broadinstitute.hellbender.tools.walkers.rnaseq.SplitNCigarReads.closeTool(SplitNCigarReads.java:187)
at org.broadinstitute.hellbender.engine.GATKTool.doWork(GATKTool.java:1052)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.runTool(CommandLineProgram.java:139)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMainPostParseArgs(CommandLineProgram.java:191)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMain(CommandLineProgram.java:210)
at org.broadinstitute.hellbender.Main.runCommandLineProgram(Main.java:163)
at org.broadinstitute.hellbender.Main.mainEntry(Main.java:206)
at org.broadinstitute.hellbender.Main.main(Main.java:292)
Any feedback and suggestions to solve this is much appreciated.
Thanks for your time and help!
-Kathie
-
Hi ,
I also tried using the latest version GATK v4.1.8.1, and I still see the same issues. Any advice and guidance is appreciated.
Thank you for your time and help.
Best Regards,
Kathie
-
Hi KATHIE NGO, this error is resulting from the program running out of space to write files. You can specify a temporary directory that has more space with the option --tmp-dir.
-
Hi Genevieve,
Thank you for your time and help. Can you please tell me where does the program write files by default, is it where the command was executed? The output BAM files are empty and we have about 2.2TB of free space in our /home directory on the server where I executed the command.
Best Regards,
Kathie
-
Hi KATHIE NGO, it depends on your system. Some systems use an automatic temporary space that has less space than necessary for some jobs. If the --tmp-dir option does not work, please let us know so we can troubleshoot from there.
-
Hi Genevieve,
Thank you for your time and help. Specifying the option --tmp-dir solved my issue.
Best Regards,
Kathie
-
Thanks for the update! Glad it worked.
-
Hello Genevieve,
I am using GATK 4.2.5.0. I am getting the same issue.
Unfortunately, my issue is not solved after specifying --tmp-dir.
Any other suggestion?
Thanks and regards,
Jay
-
Hi JAY SINGH,
Could you give more details about your issue, including the command and the error message?
Thank you,
Genevieve
-
Hi
I am using GATK SplitNCigarReads version 4.0.5.1
And getting an error (attached)
gatk SplitNCigarReads -R SplitNCigar_Reads/human_genome.fna -I Mark_duplicates/PicardOutput/sorted_unique_reads_withRGAlignment/SRR1rtgtrr_Unique_reads_WithRG.bam -O SplitNCigar_Reads/output/SRR1rtgtrr_SplitNCigar_out.bam --sites-only-vcf-output true --TMP_DIR TMP_DIR
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:80: SyntaxWarning: "is" with a literal. Did you mean "=="?
if len(args) is 0 or (len(args) is 1 and (args[0] == "--help" or args[0] == "-h")):
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:80: SyntaxWarning: "is" with a literal. Did you mean "=="?
if len(args) is 0 or (len(args) is 1 and (args[0] == "--help" or args[0] == "-h")):
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:117: SyntaxWarning: "is" with a literal. Did you mean "=="?
if len(args) is 1 and args[0] == "--list":
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:301: SyntaxWarning: "is" with a literal. Did you mean "=="?
if call(["gsutil", "-q", "stat", gcsjar]) is 0:
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:305: SyntaxWarning: "is" with a literal. Did you mean "=="?
if call(["gsutil", "cp", jar, gcsjar]) is 0:
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:458: SyntaxWarning: "is not" with a literal. Did you mean "!="?
if not len(properties) is 0:
/DATA/RamanDeep/Tools/anaconda3/bin/gatk:462: SyntaxWarning: "is not" with a literal. Did you mean "!="?
if not len(filesToAdd) is 0:
Using GATK jar /DATA/RamanDeep/Tools/anaconda3/share/gatk4-4.0.5.1-0/gatk-package-4.0.5.1-local.jar
Running:
java -Dsamjdk.use_async_io_read_samtools=false -Dsamjdk.use_async_io_write_samtools=true -Dsamjdk.use_async_io_write_tribble=false -Dsamjdk.compression_level=2 -jar /DATA/RamanDeep/Tools/anaconda3/share/gatk4-4.0.5.1-0/gatk-package-4.0.5.1-local.jar SplitNCigarReads -R SplitNCigar_Reads/human_genome.fna -I Mark_duplicates/PicardOutput/sorted_unique_reads_withRGAlignment/SRR1rtgtrr_Unique_reads_WithRG.bam -O SplitNCigar_Reads/output/SRR1rtgtrr_SplitNCigar_out.bam --sites-only-vcf-output true --TMP_DIR TMP_DIR
18:44:57.015 INFO NativeLibraryLoader - Loading libgkl_compression.so from jar:file:/DATA/RamanDeep/Tools/anaconda3/share/gatk4-4.0.5.1-0/gatk-package-4.0.5.1-local.jar!/com/intel/gkl/native/libgkl_compression.so
18:44:57.234 INFO SplitNCigarReads - ------------------------------------------------------------
18:44:57.234 INFO SplitNCigarReads - The Genome Analysis Toolkit (GATK) v4.0.5.1
18:44:57.235 INFO SplitNCigarReads - For support and documentation go to https://software.broadinstitute.org/gatk/
18:44:57.235 INFO SplitNCigarReads - Executing as niharika@user on Linux v4.15.0-213-generic amd64
18:44:57.235 INFO SplitNCigarReads - Java runtime: OpenJDK 64-Bit Server VM v1.8.0_382-b05
18:44:57.235 INFO SplitNCigarReads - Start Date/Time: 30 November, 2023 6:44:57 PM IST
18:44:57.235 INFO SplitNCigarReads - ------------------------------------------------------------
18:44:57.235 INFO SplitNCigarReads - ------------------------------------------------------------
18:44:57.235 INFO SplitNCigarReads - HTSJDK Version: 2.15.1
18:44:57.235 INFO SplitNCigarReads - Picard Version: 2.18.2
18:44:57.235 INFO SplitNCigarReads - HTSJDK Defaults.COMPRESSION_LEVEL : 2
18:44:57.235 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_READ_FOR_SAMTOOLS : false
18:44:57.235 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_SAMTOOLS : true
18:44:57.235 INFO SplitNCigarReads - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_TRIBBLE : false
18:44:57.236 INFO SplitNCigarReads - Deflater: IntelDeflater
18:44:57.236 INFO SplitNCigarReads - Inflater: IntelInflater
18:44:57.236 INFO SplitNCigarReads - GCS max retries/reopens: 20
18:44:57.236 INFO SplitNCigarReads - Using google-cloud-java patch 6d11bef1c81f885c26b2b56c8616b7a705171e4f from https://github.com/droazen/google-cloud-java/tree/dr_all_nio_fixes
18:44:57.236 INFO SplitNCigarReads - Initializing engine
18:44:57.686 INFO SplitNCigarReads - Done initializing engine
18:44:57.729 INFO SplitNCigarReads - Shutting down engine
[30 November, 2023 6:44:57 PM IST] org.broadinstitute.hellbender.tools.walkers.rnaseq.SplitNCigarReads done. Elapsed time: 0.01 minutes.
Runtime.totalMemory()=2175270912
htsjdk.samtools.util.RuntimeIOException: Error opening file: file:///DATA1/Niharika/NSCLC_DATA_ANALYSIS/RE_ANALYSIS_RNA_SEQ/SplitNCigar_Reads/output/SRR1rtgtrr_SplitNCigar_out.bam
at htsjdk.samtools.SAMFileWriterFactory.makeBAMWriter(SAMFileWriterFactory.java:302)
at htsjdk.samtools.SAMFileWriterFactory.makeBAMWriter(SAMFileWriterFactory.java:259)
at htsjdk.samtools.SAMFileWriterFactory.makeSAMOrBAMWriter(SAMFileWriterFactory.java:435)
at htsjdk.samtools.SAMFileWriterFactory.makeWriter(SAMFileWriterFactory.java:474)
at org.broadinstitute.hellbender.utils.read.ReadUtils.createCommonSAMWriterFromFactory(ReadUtils.java:1183)
at org.broadinstitute.hellbender.utils.read.ReadUtils.createCommonSAMWriter(ReadUtils.java:1131)
at org.broadinstitute.hellbender.engine.GATKTool.createSAMWriter(GATKTool.java:772)
at org.broadinstitute.hellbender.tools.walkers.rnaseq.SplitNCigarReads.onTraversalStart(SplitNCigarReads.java:170)
at org.broadinstitute.hellbender.engine.GATKTool.doWork(GATKTool.java:992)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.runTool(CommandLineProgram.java:135)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMainPostParseArgs(CommandLineProgram.java:180)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMain(CommandLineProgram.java:199)
at org.broadinstitute.hellbender.Main.runCommandLineProgram(Main.java:160)
at org.broadinstitute.hellbender.Main.mainEntry(Main.java:203)
at org.broadinstitute.hellbender.Main.main(Main.java:289)
Caused by: java.nio.file.NoSuchFileException: SplitNCigar_Reads/output/SRR1rtgtrr_SplitNCigar_out.bam
at sun.nio.fs.UnixException.translateToIOException(UnixException.java:86)
at sun.nio.fs.UnixException.rethrowAsIOException(UnixException.java:102)
at sun.nio.fs.UnixException.rethrowAsIOException(UnixException.java:107)
at sun.nio.fs.UnixFileSystemProvider.newByteChannel(UnixFileSystemProvider.java:214)
at java.nio.file.spi.FileSystemProvider.newOutputStream(FileSystemProvider.java:434)
at java.nio.file.Files.newOutputStream(Files.java:216)
at htsjdk.samtools.SAMFileWriterFactory.makeBAMWriter(SAMFileWriterFactory.java:290)
... 14 more
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