RemoveNearbyIndels: CRSP
"This is a preprocessing step for the CRSP sensitivity validation truth data"
what's the meaning of "CRSP",
Clinical Research Sequencing Platform (CRSP)?
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Not a googlable question....
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Hi Andrew Zhang
CRSP is the Broad Clinical Research Sequencing Platform. It was developed since they needed it and we made it available as part of the Mutect2 validation tools.
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Hello Bhanu:
Many thanks,I am wondering is it necessary to remove nearby INDEL,when I was trying to get the de novo mutation using HaplotypeCaller.
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Hi Andrew,
Depends on your experimental design and what it is that you are trying to do. Can you explain that a little more?
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Hi Bhanu,
It is to use the candidate list currently obtained through the VCF file of the parents and child. Then through some reasonable steps, reduce the false positive rate of spontaneous mutations, thereby reducing the workload of subsequent experimental verification.
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Hi Andrew Zhang
We do not recommend using this tool. This was developed for a very specific internal purposes only.
Going forward we are going to make it very clear in our documentation that this is not for external use.
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