Genome Analysis Toolkit

Variant Discovery in High-Throughput Sequencing Data

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Developed in the Data Sciences Platform at the Broad Institute, the toolkit offers a wide variety of tools with a primary focus on variant discovery and genotyping. Its powerful processing engine and high-performance computing features make it capable of taking on projects of any size. Learn more

(How to) Filter variants either with VQSR or by hard-filtering Follow

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    Andrew Zhang

    Very useful ! Well, I am wondering if the data is whole genome sequencing,is it necessary to add DP < min || DP > 2.5 times avrage depth in Hard-filter step

    Look forward to your favourable reply.


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